KYNU

Description		kynureninase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Hydrolase Activity Pyridoxal Phosphate Binding Kynureninase Activity Protein Homodimerization Activity
	Biological Process	L-tryptophan Catabolic Process Nucleoside Phosphate Metabolic Process NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process L-tryptophan Catabolic Process To Kynurenine Quinolinate Biosynthetic Process Response To Type II Interferon 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Response To Vitamin B6 Anthranilate Metabolic Process Purine-containing Compound Metabolic Process L-kynurenine Catabolic Process
Pathways		Tryptophan catabolism
Drugs		Pyridoxal phosphate Alanine m-Hydroxyhippuric acid
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Asthma and eczema ( 34155719) Blood protein levels ( 30072576) Cataracts ( 34127677) Empathy quotient ( 29527006) Glomerular filtration rate in chronic kidney disease ( 26420894) Neurological blood protein biomarker levels ( 31320639) Platelet count ( 32888494) Response to SSRI (symptom remission) ( 29160301) Toenail selenium levels ( 25343990)
Interacting Genes		9 interacting genes: CDC42 CT55 CTBP2 FAM86C1P LMO4 MCCD1 MYOZ3 PIP4K2B RASSF3
Entrez ID		8942
HPRD ID		08940
Ensembl ID		ENSG00000115919
Uniprot IDs		Q16719 Q53SX6
PDB IDs		2HZP 3E9K 7S3V
Enriched GO Terms of Interacting Partners?
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