MIR34B and CELF1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR34B	CELF1
Description		microRNA 34b	CUGBP Elav-like family member 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Membrane Perinucleolar Compartment Ribonucleoprotein Complex
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Pre-mRNA Binding BRE Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Processing Germ Cell Development Negative Regulation Of Cell Population Proliferation RNA Splicing Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Post-transcriptional Gene Silencing Negative Regulation Of Translation Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of RNA Splicing Regulation Of Inflammatory Response MRNA Destabilization
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Immature fraction of reticulocytes ( 32888494 27863252) Loneliness ( 29970889 31518406) Loneliness (MTAG) ( 29970889) Metabolic syndrome ( 31589552) Neuroticism ( 29255261) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Platelet count ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Sleep duration (short sleep) ( 30846698) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		109 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR ATXN2 ATXN2L C1QBP CDC5L CELF1 CELF2 CPSF1 CPSF7 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MTERF3 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PIP5K1A PLOD1 PTBP1 PTBP3 PTCD3 PUF60 PURA PURB QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RBM45 RBM4B RTCA RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM56 U2SURP UPF1 USP36 UTP20 WDR33 XAB2 YBX1 YBX2 YBX3 ZFR ZNF346	49 interacting genes: APP CEBPA DMPK FUBP1 MIR106B MIR107 MIR10B MIR128-1 MIR138-2 MIR140 MIR143 MIR155 MIR15B MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR25 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I OGT PPBP RALY RNF10 TOM1L1
Entrez ID		407041	10658
HPRD ID			03046
Ensembl ID		ENSG00000207811	ENSG00000149187
Uniprot IDs			G5EA30 Q92879
PDB IDs			2CPZ 2DHS 2RQ4 2RQC 3NMR 3NNA 3NNC 3NNH
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleus Regulation Of MRNA Metabolic Process Nucleoplasm Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Translation TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization TRNA Aminoacylation MRNA Stabilization Regulation Of Primary Metabolic Process Regulation Of RNA Stability RNA Transport Regulation Of MRNA Stability U2 SnRNP Positive Regulation Of Gene Expression Regulation Of Metabolic Process Ligase Activity Protein-RNA Complex Assembly	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Developmental Process Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Translation MRNA Destabilization RNA Destabilization Extracellular Space Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Positive Regulation Of MRNA Catabolic Process Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cytokine Production Regulation Of Locomotion Regulation Of Developmental Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process
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