MIR34B and TRIM56

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR34B	TRIM56
Description		microRNA 34b	tripartite motif containing 56
Image		No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Cytoplasm Cytosol
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Immune System Process Protein Monoubiquitination Protein Ubiquitination Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Response To Type I Interferon Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K63-linked Ubiquitination CGAS/STING Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			Regulation of innate immune responses to cytosolic DNA
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756)	Alzheimer's disease ( 30636644) Nonunion in individuals with fractures ( 30680360)
Interacting Genes		109 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR ATXN2 ATXN2L C1QBP CDC5L CELF1 CELF2 CPSF1 CPSF7 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MTERF3 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PIP5K1A PLOD1 PTBP1 PTBP3 PTCD3 PUF60 PURA PURB QARS1 QKI RARS1 RBFOX2 RBM14 RBM4 RBM45 RBM4B RTCA RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM56 U2SURP UPF1 USP36 UTP20 WDR33 XAB2 YBX1 YBX2 YBX3 ZFR ZNF346	5 interacting genes: MIR200C MIR25 MIR34B UBE2H WEE2-AS1
Entrez ID		407041	81844
HPRD ID			10284
Ensembl ID		ENSG00000207811	ENSG00000169871
Uniprot IDs			Q9BRZ2
PDB IDs			5JW7
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleus Regulation Of MRNA Metabolic Process Nucleoplasm Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome Spliceosomal Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation Cytoplasmic Stress Granule Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Translation TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization TRNA Aminoacylation MRNA Stabilization Regulation Of Primary Metabolic Process Regulation Of RNA Stability RNA Transport Regulation Of MRNA Stability U2 SnRNP Positive Regulation Of Gene Expression Regulation Of Metabolic Process Ligase Activity Protein-RNA Complex Assembly	MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Muscle System Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Cardiac Muscle Hypertrophy RISC Complex MRNA Destabilization RNA Destabilization Regulation Of System Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Transmembrane Transport MRNA 3'-UTR Binding Negative Regulation Of Interleukin-33 Production Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Mesodermal Cell Differentiation Pre-mRNA 5'-splice Site Binding Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Calcium Ion Import Across Plasma Membrane MRNA 5'-splice Site Recognition Regulation Of Response To Drug Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endothelial Cell Differentiation Regulation Of Connective Tissue Replacement Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Multicellular Organismal Development U1 SnRNP Negative Regulation Of Transport Positive Regulation Of Tissue Remodeling Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Ubiquitin Conjugating Enzyme Activity MRNA Splice Site Recognition
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