ROPN1L and AKAP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ROPN1L	AKAP5
Description		rhophilin associated tail protein 1 like	A-kinase anchoring protein 5
Image
GO Annotations	Cellular Component	Radial Spoke Extracellular Region Nucleoplasm Cytoplasm Cilium Motile Cilium Cell Projection	Endosome Cytosol Plasma Membrane Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Dendrite Membrane Cell Projection Dendritic Spine Membrane Raft Synapse Postsynaptic Membrane Excitatory Synapse Postsynaptic Recycling Endosome Postsynaptic Recycling Endosome Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Calmodulin Binding Adenylate Cyclase Binding SH3 Domain Binding Protein Phosphatase 2B Binding Beta-2 Adrenergic Receptor Binding Protein Kinase A Regulatory Subunit Binding Glutamate Receptor Binding GABA Receptor Binding Protein Kinase A Binding Molecular Adaptor Activity Scaffold Protein Binding
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Flagellated Sperm Motility Sperm Capacitation	Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Regulation Of Protein Kinase A Signaling Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Endosome To Plasma Membrane Protein Transport
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs
Diseases
GWAS		Body mass index ( 22446040) Breast cancer ( 21424380) Coronary artery disease in type 1 diabetes ( 29695241) Dermatomyositis or juvenile dermatomyositis ( 26362759) Mean arterial pressure ( 27618448) Triglyceride levels ( 31170924)
Interacting Genes		7 interacting genes: AKAP14 AKAP3 AKAP5 AKAP7 APP BEX2 RSPH3	21 interacting genes: ADRB2 CALM1 DLG1 DLG4 FOS GABRB1 GABRB3 IQGAP1 JUN KCNJ2 MDM2 PPP3CA PRKAR1A PRKAR2A PRKAR2B PRKCA RET ROPN1 ROPN1L TP53 TRPV1
Entrez ID		83853	9495
HPRD ID		17986	05255
Ensembl ID		ENSG00000145491	ENSG00000179841
Uniprot IDs		Q96C74	P24588 Q6PG46
PDB IDs		8J07	2H9R 3LL8 5NIN
Enriched GO Terms of Interacting Partners?		Protein Kinase A Binding Protein Kinase A Regulatory Subunit Binding Positive Regulation Of Long-term Synaptic Potentiation Dendrite Membrane Regulation Of Long-term Synaptic Potentiation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Calcium-mediated Signaling Cellular Response To CAMP Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Metal Ion Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Modulation Of Chemical Synaptic Transmission Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Calcium-mediated Signaling Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cell Projection Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Endosome To Plasma Membrane Protein Transport Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Positive Regulation Of Synaptic Transmission Astrocyte Activation Involved In Immune Response Dendritic Spine Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Calcium-mediated Signaling Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding	Regulation Of Membrane Potential Intracellular Signal Transduction Response To Metal Ion Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction CAMP-dependent Protein Kinase Regulator Activity Regulation Of Biological Quality Regulation Of System Process CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Regulation Of CAMP/PKA Signal Transduction Regulation Of Muscle System Process Response To Calcium Ion Protein Kinase A Catalytic Subunit Binding Regulation Of Multicellular Organismal Process Dendritic Spine Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Developmental Process Cellular Response To Metal Ion CAMP Binding Plasma Membrane System Process Glutamatergic Synapse Cellular Response To Actinomycin D Positive Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Response To Steroid Hormone Enzyme Binding Response To Toxic Substance Regulation Of Postsynaptic Membrane Potential Protein Domain Specific Binding Postsynaptic Membrane Response To Actinomycin D Extracellular Ligand-gated Monoatomic Ion Channel Activity Muscle System Process Cellular Response To UV-C Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Glomerulus Development Learning Or Memory Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ciliary Base Modulation Of Chemical Synaptic Transmission Transcription Factor AP-1 Complex Cellular Response To Histamine Response To Xenobiotic Stimulus
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