INO80B and IGFBP2

Number of citations of the paper that reports this interaction (PubMedID 19095771)
34

Data Source:
BioGRID (pull down, affinity chromatography technology)

		INO80B	IGFBP2
Description		INO80 complex subunit B	insulin like growth factor binding protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body Ino80 Complex	Extracellular Region Extracellular Space Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Phosphatase Inhibitor Activity Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Signaling Receptor Inhibitor Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Receptor Ligand Inhibitor Activity
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Osteoblast Differentiation Female Pregnancy Response To Nutrient Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Positive Regulation Of Activated T Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Negative Regulation Of Osteoblast Differentiation Response To Steroid Hormone Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		UCH proteinases DNA Damage Recognition in GG-NER	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Glomerular filtration rate (creatinine) ( 28452372) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Mitral valve prolapse ( 26301497) Thyroid stimulating hormone levels ( 25743335) Type 2 diabetes ( 26818947)
Interacting Genes		64 interacting genes: ABI2 BANP BOLL CARD9 CAVIN1 CCDC85B CD81 CDR2L CEP70 CSNK2B CYSRT1 DPPA4 DVL3 E2F6 FLACC1 GOLGA6L9 GPRASP3 HMBOX1 HMGXB4 HOMEZ HOXA1 HSF2BP IGFBP2 KCTD7 KRT34 KRT40 KRTAP10-8 KRTAP12-2 KRTAP19-1 KRTAP6-2 LHX4 LIMS1 LZTS2 MID2 MKRN3 MORN3 MTUS2 MYLIP NBPF19 NOTCH2NLA PICK1 PIP4K2B PLAGL2 PNMA1 PNMA2 RBM39 RIMBP3C SOX13 SSX2IP STAC3 THAP1 TLE5 TNS2 TRAF2 TRIB3 TRIM27 TSPYL2 U2AF2 UIMC1 USH1G YAF2 ZNF526 ZNF552 ZRANB1	6 interacting genes: GSDMB IGF1 IGF2 INO80B KLK2 TF
Entrez ID		83444	3485
HPRD ID		17110	00898
Ensembl ID		ENSG00000115274	ENSG00000115457
Uniprot IDs		Q9C086	C9JMY1 P18065
PDB IDs		6HTS 7ZI4	2H7T
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Intermediate Filament	Lung Vasculature Development Positive Regulation Of Growth Exocrine Pancreas Development Osteoblast Differentiation Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Developmental Growth Insulin Receptor Binding Epithelial Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cellular Component Organization Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Regulation Of Glycogen Metabolic Process Blood Vessel Remodeling Regulation Of Activated T Cell Proliferation Lung Alveolus Development Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Vasculature Development Extracellular Space Proteoglycan Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Developmental Growth Basal Plasma Membrane Platelet Alpha Granule Lumen Negative Regulation Of Oocyte Development Clathrin-coated Pit Negative Regulation Of Muscle Cell Differentiation Striated Muscle Cell Differentiation Positive Regulation Of Osteoblast Differentiation Insulin Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Tissue Remodeling Proteoglycan Metabolic Process Positive Regulation Of Cell Activation Regulation Of Cell Growth Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Organ Growth Cytotoxic T Cell Pyroptotic Cell Death Positive Regulation Of RNA Metabolic Process Regulation Of Glucose Metabolic Process Secretory Granule
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