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HIST1H2AB and ERCC6
Number of citations of the paper that reports this interaction (PMID
11003660
)
80
Data Source:
BioGRID
(far western blotting)
HIST1H2AB
ERCC6
Gene Name
histone cluster 1, H2ab
excision repair cross-complementation group 6
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Nucleolus
Transcription Elongation Factor Complex
Molecular Function
DNA Binding
Protein Heterodimerization Activity
DNA Binding
DNA Helicase Activity
Chromatin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Protein Tyrosine Kinase Activator Activity
Protein Complex Binding
Protein N-terminus Binding
Biological Process
Biological_process
Response To Superoxide
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Pyrimidine Dimer Repair
Transcription Elongation From RNA Polymerase I Promoter
Transcription From RNA Polymerase II Promoter
Response To Oxidative Stress
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Response To X-ray
Response To UV-B
Response To Gamma Radiation
Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Multicellular Organism Growth
Photoreceptor Cell Maintenance
Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Nucleotide Excision Repair
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Transcription-coupled NER (TC-NER)
RNA Polymerase I Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
Formation of transcription-coupled NER (TC-NER) repair complex
Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
BRCA1
CDK1
CDK2
EP300
ERCC6
KAT2B
RNF2
UHRF1
USP16
15 interactors:
BRCA1
CHEK2
ERCC5
ERCC8
GTF2E2
HIST1H2AB
HIST1H2BB
HIST1H3A
HIST1H4A
PARP1
POLR2A
RNF11
TP53
XAB2
XPA
Entrez ID
8335
2074
HPRD ID
09105
00596
Ensembl ID
ENSG00000137259
ENSG00000225830
Uniprot IDs
P04908
Q08AJ9
Q03468
Q59FF6
Q8N328
PDB IDs
2CV5
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3W96
3W97
3W98
3W99
Enriched GO Terms of Interacting Partners
?
Histone Modification
Chromatin Modification
Chromatin Organization
Cell Cycle
Cellular Response To DNA Damage Stimulus
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Chromosome Organization
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
Cellular Response To Stress
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
N-terminal Peptidyl-lysine Acetylation
Nucleobase-containing Compound Metabolic Process
Cell Cycle Process
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Organelle Organization
Centrosome Cycle
Cellular Nitrogen Compound Metabolic Process
Cellular Protein Modification Process
DNA Repair
Positive Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Mitotic Cell Cycle
Centrosome Organization
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Microtubule Organizing Center Organization
N-terminal Protein Amino Acid Acetylation
Signal Transduction By P53 Class Mediator
Cellular Protein Metabolic Process
Regulation Of Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Positive Regulation Of Transcription From RNA Polymerase II Promoter
DNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
DNA Damage Checkpoint
DNA Metabolic Process
DNA Repair
Nucleotide-excision Repair
Cellular Response To DNA Damage Stimulus
Transcription-coupled Nucleotide-excision Repair
Cellular Response To Stress
Response To Radiation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Response To UV
Chromatin Assembly
Response To Ionizing Radiation
Cellular Nitrogen Compound Metabolic Process
Double-strand Break Repair
Chromatin Assembly Or Disassembly
Protein Autoubiquitination
DNA Packaging
Intrinsic Apoptotic Signaling Pathway
Nitrogen Compound Metabolic Process
Response To Stress
DNA Replication-dependent Nucleosome Assembly
DNA Conformation Change
Signal Transduction In Response To DNA Damage
DNA Methylation On Cytosine
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Response To Abiotic Stimulus
DNA Damage Response, Signal Transduction Resulting In Transcription
Chromatin Silencing At RDNA
Response To Light Stimulus
Replicative Senescence
Apoptotic Signaling Pathway
Nucleosome Assembly
Nucleotide-excision Repair, DNA Damage Removal
Nucleosome Organization
Negative Regulation Of Biosynthetic Process
DNA Damage Checkpoint
Response To Oxidative Stress
Cellular Macromolecule Catabolic Process
Response To X-ray
Protein-DNA Complex Assembly
Transcription Initiation From RNA Polymerase II Promoter
Chromatin Silencing
Positive Regulation Of DNA Repair
Regulation Of Gene Expression, Epigenetic
Chromosome Organization
Protein Complex Assembly
Negative Regulation Of Reactive Oxygen Species Metabolic Process
DNA-templated Transcription, Initiation
Tagcloud
?
abca1
adamtsl3
aiming
apc
crc
elac1
epha3
ephb6
excluding
exome
fbxw7
germline
kbiosciences
marginal
mll3
obscn
pkhd1
recessive
rs4987622
rs6464211
rs6947538
silico
smad4
snps
somatic
spite
strongest
syne1
trpv6
Tagcloud (Difference)
?
abca1
adamtsl3
aiming
apc
crc
elac1
epha3
ephb6
excluding
exome
fbxw7
germline
kbiosciences
marginal
mll3
obscn
pkhd1
recessive
rs4987622
rs6464211
rs6947538
silico
smad4
snps
somatic
spite
strongest
syne1
trpv6
Tagcloud (Intersection)
?