LAGE3 and PSMB9

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		LAGE3	PSMB9
Name		L antigen family member 3	proteasome 20S subunit beta 9
Structure
GO Annotations	Cellular Component	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Nuclear Body	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex
	Molecular Function	Protein Binding	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	TRNA Processing TRNA Threonylcarbamoyladenosine Metabolic Process	Immune System Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		tRNA modification in the nucleus and cytosol	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs		None	Carfilzomib
GWAS		No GWAS studies recorded	Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Crohn's disease ( 23266558 ) Disc degeneration (lumbar) ( 22993228 ) Hip circumference adjusted for BMI ( 34021172 ) IgA nephropathy ( 25305756 ) Nephropathy ( 21399633 ) Platelet distribution width ( 27863252 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Systemic lupus erythematosus ( 32771030 )
Novel Interactors		None recorded	4 novel interactors: BRD2 DYNC1H1 NDUFB9 PTK7
Interacting Genes		22 interacting genes: AKAP8L CYSRT1 GOLGA6L9 GON7 HSF2BP HYKK KRT40 KRTAP10-8 KRTAP6-3 MID2 MIPOL1 MKRN3 OSGEP PDE9A PLEKHJ1 PNMA1 POP7 PSMB9 TRIM23 TRIM27 TRIM55 VPS37C	8 interacting genes: CRYGA DDIT4L LAGE3 NCOA1 NCOA2 NCOA3 POMP PSMB10
Entrez ID		8270	5698
HPRD ID		02087	01514
Ensembl ID		ENSG00000196976	ENSG00000240065
Uniprot IDs		Q14657	A0A1U9X8D7 P28065
PDB IDs		6GWJ	6AVO 6E5B 7AWE 7B12 9FST
GO Terms Enriched among Interactors		EKC/KEOPS Complex TRNA Threonylcarbamoyladenosine Modification Ubiquitin Protein Ligase Activity Identical Protein Binding Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Viral Transcription TRNA Threonylcarbamoyladenosine Metabolic Process TRNA Processing Protein Ubiquitination Intermediate Filament Amino Acid Kinase Activity Hydroxylysine Kinase Activity Positive Regulation Of Autophagy Protein Modification By Small Protein Conjugation	Cellular Response To Thyroglobulin Triiodothyronine Nuclear Receptor Binding Response To Thyroglobulin Triiodothyronine Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Nuclear Receptor-mediated Signaling Pathway Regulation Of Adipose Tissue Development Protein-lysine-acetyltransferase Activity Protein Dimerization Activity Histone Acetyltransferase Activity Response To Progesterone Intracellular Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose MRNA Transcription Transcription Coactivator Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Acetylation-dependent Protein Binding Labyrinthine Layer Morphogenesis Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Neural Tube Closure Tube Closure Response To Lipid Positive Regulation Of Female Receptivity Response To Retinoic Acid Histone H3K14ac Reader Activity Response To Estradiol Vitamin D Receptor Signaling Pathway