LAGE3 and HYKK

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LAGE3	HYKK
Description		L antigen family member 3	hydroxylysine kinase
Image			No pdb structure
GO Annotations	Cellular Component	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Nuclear Body	Cytoplasm Mitochondrial Matrix
	Molecular Function	Protein Binding	Kinase Activity Transferase Activity Amino Acid Kinase Activity Hydroxylysine Kinase Activity
	Biological Process	TRNA Processing TRNA Threonylcarbamoyladenosine Metabolic Process	Lysine Catabolic Process
Pathways		tRNA modification in the nucleus and cytosol	Lysine catabolism
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Schizophrenia ( 29483656)
Interacting Genes		22 interacting genes: AKAP8L CYSRT1 GOLGA6L9 GON7 HSF2BP HYKK KRT40 KRTAP10-8 KRTAP6-3 MID2 MIPOL1 MKRN3 OSGEP PDE9A PLEKHJ1 PNMA1 POP7 PSMB9 TRIM23 TRIM27 TRIM55 VPS37C	3 interacting genes: GMCL1 LAGE3 TRIP6
Entrez ID		8270	123688
HPRD ID		02087	12515
Ensembl ID		ENSG00000196976	ENSG00000188266
Uniprot IDs		Q14657	A2RU49
PDB IDs		6GWJ
Enriched GO Terms of Interacting Partners?		EKC/KEOPS Complex TRNA Threonylcarbamoyladenosine Modification Ubiquitin Protein Ligase Activity Identical Protein Binding Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Viral Transcription TRNA Threonylcarbamoyladenosine Metabolic Process TRNA Processing Protein Ubiquitination Intermediate Filament Amino Acid Kinase Activity Hydroxylysine Kinase Activity Positive Regulation Of Autophagy Protein Modification By Small Protein Conjugation
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