PSMB9 and PSMB10

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vivo)

		PSMB9	PSMB10
Name		proteasome 20S subunit beta 9	proteasome 20S subunit beta 10
Structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Spermatoproteasome Complex
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Immune System Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Cell Morphogenesis Proteolysis Humoral Immune Response T Cell Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs		Carfilzomib	Carfilzomib
GWAS		Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Crohn's disease ( 23266558 ) Disc degeneration (lumbar) ( 22993228 ) Hip circumference adjusted for BMI ( 34021172 ) IgA nephropathy ( 25305756 ) Nephropathy ( 21399633 ) Platelet distribution width ( 27863252 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Systemic lupus erythematosus ( 32771030 )	Crohn's disease ( 22412388 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )
Novel Interactors		4 novel interactors: BRD2 DYNC1H1 NDUFB9 PTK7	1 novel interactors: PSKH1
Interacting Genes		8 interacting genes: CRYGA DDIT4L LAGE3 NCOA1 NCOA2 NCOA3 POMP PSMB10	11 interacting genes: ANXA7 CCNDBP1 CRX MEOX2 POMP PSMA1 PSMA2 PSMA3 PSMB8 PSMB9 PTN
Entrez ID		5698	5699
HPRD ID		01514	01465
Ensembl ID		ENSG00000240065	ENSG00000205220
Uniprot IDs		A0A1U9X8D7 P28065	P40306
PDB IDs		6AVO 6E5B 7AWE 7B12 9FST	6AVO 6E5B 6HV3 6HV4 6HV5 6HV7 6HVA 6HVR 6HVS 6HVT 6HVU 6HVV 6HVW 7AWE 7B12 9FSV
GO Terms Enriched among Interactors		Cellular Response To Thyroglobulin Triiodothyronine Nuclear Receptor Binding Response To Thyroglobulin Triiodothyronine Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Nuclear Receptor-mediated Signaling Pathway Regulation Of Adipose Tissue Development Protein-lysine-acetyltransferase Activity Protein Dimerization Activity Histone Acetyltransferase Activity Response To Progesterone Intracellular Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose MRNA Transcription Transcription Coactivator Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Acetylation-dependent Protein Binding Labyrinthine Layer Morphogenesis Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Neural Tube Closure Tube Closure Response To Lipid Positive Regulation Of Female Receptivity Response To Retinoic Acid Histone H3K14ac Reader Activity Response To Estradiol Vitamin D Receptor Signaling Pathway	Proteasome Core Complex Proteasome Complex Proteasome Core Complex, Alpha-subunit Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spermatoproteasome Complex Proteasomal Protein Catabolic Process Threonine-type Endopeptidase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome Core Complex, Beta-subunit Complex Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nucleus Macromolecule Catabolic Process Proteolysis Catabolic Process Extracellular Exosome Dendrite Regeneration Endopeptidase Activity Ossification Involved In Bone Remodeling Nuclear Speck