PSMB9

Description		proteasome 20S subunit beta 9
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Immune System Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs		Carfilzomib
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 23266558) Disc degeneration (lumbar) ( 22993228) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Nephropathy ( 21399633) Platelet distribution width ( 27863252) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Systemic lupus erythematosus ( 32771030)
Novel Interacting Genes		4 novel interacting genes: BRD2 DYNC1H1 NDUFB9 PTK7
Interacting Genes		8 interacting genes: CRYGA DDIT4L LAGE3 NCOA1 NCOA2 NCOA3 POMP PSMB10
Entrez ID		5698
HPRD ID		01514
Ensembl ID		ENSG00000240065
Uniprot IDs		A0A1U9X8D7 P28065
PDB IDs		6AVO 6E5B 7AWE 7B12 9FST
Enriched GO Terms of Interacting Partners?		Cellular Response To Thyroglobulin Triiodothyronine Nuclear Receptor Binding Response To Thyroglobulin Triiodothyronine Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Nuclear Receptor-mediated Signaling Pathway Regulation Of Adipose Tissue Development Protein-lysine-acetyltransferase Activity Protein Dimerization Activity Histone Acetyltransferase Activity Response To Progesterone Intracellular Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose MRNA Transcription Transcription Coactivator Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Acetylation-dependent Protein Binding Labyrinthine Layer Morphogenesis Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Neural Tube Closure Tube Closure Response To Lipid Positive Regulation Of Female Receptivity Response To Retinoic Acid Histone H3K14ac Reader Activity Response To Estradiol Vitamin D Receptor Signaling Pathway
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