KDM5C and TRIM11

Number of citations of the paper that reports this interaction (PubMedID 36192394)
44

Data Source:
BioGRID (enzymatic study)

		KDM5C	TRIM11
Description		lysine demethylase 5C	tripartite motif containing 11
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Metal Ion Binding Dioxygenase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Rhythmic Process	Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Innate Immune Response Negative Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Neurogenesis Defense Response To Virus Protein Autoubiquitination Negative Regulation Of AIM2 Inflammasome Complex Assembly
Pathways		HDMs demethylate histones	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Monocyte percentage of white cells ( 32888494)	Hip circumference (psychosocial stress interaction) ( 25271088) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433)
Interacting Genes		5 interacting genes: CALM1 CNOT4 H3C15 SUMO2 TRIM11	14 interacting genes: KDM5C MAPT MCL1 MECOM MED15 OGT PAX6 PHLPP1 RNF126 TRIM27 TRIM29 TRIM35 UBE2D2 USP14
Entrez ID		8242	81559
HPRD ID		02442	07429
Ensembl ID		ENSG00000126012	ENSG00000154370
Uniprot IDs		A0A6M4C8G8 A0A8I5KTT1 A0A8I5KYW1 P41229	Q96F44
PDB IDs		2JRZ 5FWJ	7QS1
Enriched GO Terms of Interacting Partners?		Presynaptic Cytosol Protein Autoubiquitination Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Modification By Small Protein Conjugation Negative Regulation Of AIM2 Inflammasome Complex Assembly Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Autophagosome Membrane Docking Post-translational Protein Modification Ubiquitin-protein Transferase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Ubiquitin Protein Ligase Activity CCR4-NOT Complex Protein Tag Activity Positive Regulation Of Viral Entry Into Host Cell Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Viral Transcription	Negative Regulation Of Metabolic Process Suppression Of Viral Release By Host Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Cytosol Response To Stress Regulation Of Protein Localization To Synapse Negative Regulation Of Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Activity Negative Regulation Of RNA Metabolic Process Apoptotic Process Cell Fate Determination Cell Death Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Programmed Cell Death Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Innate Immune Response Transferase Activity Chromatin Remodeling Neurofibrillary Tangle Assembly Protein K63-linked Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process BH Domain Binding Chromatin DNA Binding Habenula Development Pallium Development Protein O-acetylglucosaminyltransferase Activity Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System
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