KDM5C and CNOT4

Number of citations of the paper that reports this interaction (PMID 19346402)
31

Data Source:
BioGRID (enzymatic study)

		KDM5C	CNOT4
Gene Name		lysine (K)-specific demethylase 5C	CCR4-NOT transcription complex, subunit 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytosol CCR4-NOT Complex
	Molecular Function	DNA Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Histone Demethylase Activity (H3-K4 Specific)	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly(A) RNA Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Histone H3-K4 Demethylation Negative Regulation Of Transcription, DNA-templated Rhythmic Process Oxidation-reduction Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Gene Expression Protein Autoubiquitination
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CALM1 CNOT4 HIST2H3A	14 interactors: CNOT1 CNOT8 EP300 KDM5C UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		8242	4850
HPRD ID		02442	05369
Ensembl ID		ENSG00000126012	ENSG00000080802
Uniprot IDs		P41229	O95628
PDB IDs		2JRZ	1E4U 1UR6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Blood Coagulation Hemostasis Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion DNA Methylation On Cytosine Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Body Fluid Levels Wound Healing Chromatin Silencing At RDNA Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Response To Wounding Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Positive Regulation Of Phosphatase Activity Response To Corticosterone Positive Regulation Of Cation Channel Activity Response To Amphetamine Positive Regulation Of Adenylate Cyclase Activity Regulation Of Phosphoprotein Phosphatase Activity Chromatin Silencing Response To Mineralocorticoid Regulation Of Nitric-oxide Synthase Activity Substantia Nigra Development Positive Regulation Of Oxidoreductase Activity	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Protein Modification Process Protein K63-linked Ubiquitination Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen Levels Proteasomal Protein Catabolic Process Catabolic Process Protein Monoubiquitination Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression Regulation Of Innate Immune Response Cellular Response To Stress Proteolysis Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transcription, DNA-templated Histone Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Metabolic Process Histone Modification Cellular Response To Organic Substance Innate Immune Response
Tagcloud ?		architectures arx autism broadening broadly cul4b determinants di diseased dysregulated h3k4 hundreds kdm5a kmt2a kmt2c kmt2d kmt2e list mark mll5 mono monoaminergic monogenic neurodevelopmental pathophysiology psychosis trimethylated upset widespread
Tagcloud (Difference) ?		architectures arx autism broadening broadly cul4b determinants di diseased dysregulated h3k4 hundreds kdm5a kmt2a kmt2c kmt2d kmt2e list mark mll5 mono monoaminergic monogenic neurodevelopmental pathophysiology psychosis trimethylated upset widespread
Tagcloud (Intersection) ?