KDM5C

Gene Name		lysine (K)-specific demethylase 5C
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Histone Demethylase Activity (H3-K4 Specific)
	Biological Process	Chromatin Organization Transcription, DNA-templated Histone H3-K4 Demethylation Negative Regulation Of Transcription, DNA-templated Rhythmic Process Oxidation-reduction Process
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: CALM1 CNOT4 HIST2H3A
Entrez ID		8242
HPRD ID		02442
Ensembl ID		ENSG00000126012
Uniprot IDs		P41229
PDB IDs		2JRZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Blood Coagulation Hemostasis Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion DNA Methylation On Cytosine Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Body Fluid Levels Wound Healing Chromatin Silencing At RDNA Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Response To Wounding Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Positive Regulation Of Phosphatase Activity Response To Corticosterone Positive Regulation Of Cation Channel Activity Response To Amphetamine Positive Regulation Of Adenylate Cyclase Activity Regulation Of Phosphoprotein Phosphatase Activity Chromatin Silencing Response To Mineralocorticoid Regulation Of Nitric-oxide Synthase Activity Substantia Nigra Development Positive Regulation Of Oxidoreductase Activity
Tagcloud ?		architectures arx autism broadening broadly cul4b determinants di diseased dysregulated h3k4 hundreds kdm5a kmt2a kmt2c kmt2d kmt2e list mark mll5 mono monoaminergic monogenic neurodevelopmental pathophysiology psychosis trimethylated upset widespread