KDM5C

Description		lysine demethylase 5C
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Rhythmic Process
Pathways		HDMs demethylate histones
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Monocyte percentage of white cells ( 32888494)
Interacting Genes		5 interacting genes: CALM1 CNOT4 H3C15 SUMO2 TRIM11
Entrez ID		8242
HPRD ID		02442
Ensembl ID		ENSG00000126012
Uniprot IDs		A0A6M4C8G8 A0A8I5KTT1 A0A8I5KYW1 P41229
PDB IDs		2JRZ 5FWJ
Enriched GO Terms of Interacting Partners?		Presynaptic Cytosol Protein Autoubiquitination Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Modification By Small Protein Conjugation Negative Regulation Of AIM2 Inflammasome Complex Assembly Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Autophagosome Membrane Docking Post-translational Protein Modification Ubiquitin-protein Transferase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Ubiquitin Protein Ligase Activity CCR4-NOT Complex Protein Tag Activity Positive Regulation Of Viral Entry Into Host Cell Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Viral Transcription
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