FPR2 and SSMEM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FPR2	SSMEM1
Description		formyl peptide receptor 2	serine rich single-pass membrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Membrane
	Molecular Function	Amyloid-beta Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding Signaling Receptor Activity Cargo Receptor Activity RAGE Receptor Binding	Protein Binding
	Biological Process	Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Cell Communication Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Signaling Positive Regulation Of Superoxide Anion Generation Defense Response To Bacterium Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Innate Immune Response Astrocyte Activation Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis Dentinogenesis Cellular Response To Amyloid-beta
Pathways		G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Neutrophil degranulation
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Multiple sclerosis ( 24076602 31604244) Tourette syndrome ( 30818990)	Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		5 interacting genes: APOD CAMP FXYD6 LRRC25 SSMEM1	99 interacting genes: ALG3 APOA2 AQP1 AQP10 AQP3 ARLN ATP6V0C BET1 BLCAP C11orf24 C1QL4 C5 CCL4L2 CDIPT CDS2 CLRN2 CMTM7 CSGALNACT2 CTSA CXCL16 CXCL9 CYB561 CYBC1 DEFB103A DEFB103B DEFB121 EFNA5 EMD ERG28 ERMP1 FAM3C FATE1 FDPS FPR2 GJB2 GPHB5 GPR151 HMOX2 JAGN1 LAT LEPROTL1 LHFPL5 LNPEP MARCHF2 MCRS1 MFSD12 MFSD6 MIP MMD2 MS4A13 NINJ2 NIPAL4 NRM PGAP2 PLPP1 PLPP4 PLPP6 PLPPR2 RHD RTP2 RUSF1 S1PR5 SERP1 SLC35A1 SLC35E3 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC61A1 STX8 TAP1 TAS2R10 TLCD1 TM6SF2 TMEM128 TMEM14A TMEM14C TMEM203 TMEM218 TMEM222 TMEM239 TMEM243 TMEM45A TMEM60 TMEM86A TMEM86B TMEM97 TMPPE TNF TRARG1 UNC93B1 UPK1B VAMP4 YIPF6 ZFPL1
Entrez ID		2358	136263
HPRD ID		00647	14060
Ensembl ID		ENSG00000171049	ENSG00000165120
Uniprot IDs		P25090	A0A3B3ISA2 Q8WWF3
PDB IDs		6LW5 6OMM 7T6S 7T6U 7T6V 7WVV 7WVW 7WVX 7WVY 8Y62 8Y63
Enriched GO Terms of Interacting Partners?		Regulation Of Chemokine Production Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Cellular Response To Butyrate Prostaglandin Production Involved In Inflammatory Response Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Response To Butyrate I-kappaB Phosphorylation Presynaptic Membrane Regulation Of Smooth Muscle Cell-matrix Adhesion Arachidonate Metabolite Production Involved In Inflammatory Response Negative Regulation Of Lipoprotein Metabolic Process Peripheral Nervous System Axon Regeneration Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of T Cell Migration Cellular Response To Peptidoglycan Dentinogenesis Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Antimicrobial Humoral Response Structural Constituent Of Presynaptic Active Zone IkappaB Kinase Complex Ion Channel Regulator Activity Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Sodium Ion Export Across Plasma Membrane Chronic Inflammatory Response Presynaptic Active Zone Organization Cytolysis By Host Of Symbiont Cells Antifungal Humoral Response Regulation Of Antimicrobial Humoral Response Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Specific Granule Positive Regulation Of Monocyte Chemotactic Protein-1 Production Production Of Molecular Mediator Involved In Inflammatory Response Cytolysis Response To Peptidoglycan Presynaptic Active Zone Cytoplasmic Component Negative Regulation Of Lymphocyte Migration Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Response To Yeast	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Phosphatidate Phosphatase Activity Transmembrane Transport Glycerol Transmembrane Transport Carbohydrate Transport Water Transport Polyol Transmembrane Transport Phospholipid Metabolic Process Alkenylglycerophosphocholine Hydrolase Activity Fluid Transport Phospholipid Dephosphorylation Plasma Membrane Channel Activity Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Diacylglycerol Diphosphate Phosphatase Activity Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transport Carbohydrate Transmembrane Transport Amide Transport Glycerol Channel Activity Lipid Phosphatase Activity Renal Water Absorption One-carbon Compound Transport Urea Transmembrane Transporter Activity Farnesyl Diphosphate Metabolic Process Gap Junction-mediated Intercellular Transport Sphingosine-1-phosphate Phosphatase Activity CCR6 Chemokine Receptor Binding Antigen Processing And Presentation Of Peptide Antigen Response To Bacterium Chemotaxis Lysophosphatidic Acid Phosphatase Activity Inorganic Cation Transmembrane Transporter Activity Renal Water Transport Neutrophil Differentiation Glutamine Transport L-glutamine Transmembrane Transporter Activity Locomotion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Ammonium Channel Activity Urea Transmembrane Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
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