PKHD1 and CAMLG

Number of citations of the paper that reports this interaction (PubMedID 16243292)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PKHD1	CAMLG
Description		PKHD1 ciliary IPT domain containing fibrocystin/polyductin	calcium modulating ligand
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Extracellular Region Nucleus Chromosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium External Side Of Plasma Membrane Membrane Apical Plasma Membrane Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle 9+0 Non-motile Cilium	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Kidney Development Regulation Of Cell-matrix Adhesion Epithelial Cell Morphogenesis Intracellular Calcium Ion Homeostasis Positive Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Regulation Of TOR Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Homeostatic Process Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Establishment Of Centrosome Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cilium Assembly Regulation Of ERK1 And ERK2 Cascade Regulation Of Establishment Of Planar Polarity Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Regulation Of Cholangiocyte Proliferation	B Cell Homeostasis Receptor Recycling Defense Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Insertion Into ER Membrane Protein Stabilization Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			Cyclosporine Voclosporin
Diseases		Polycystic kidney disease
GWAS		Adult body size ( 32376654) Alcohol use disorder ( 30940813) Body size at age 10 ( 32376654) Caffeine consumption from coffee ( 33287642) Caffeine consumption from tea ( 33287642) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronotype ( 30696823) Coffee consumption ( 31046077) Diastolic blood pressure ( 27841878 28135244) Epigenetic age acceleration in alcohol use disorder ( 31466081) Estimated glomerular filtration rate ( 31152163) Fruit consumption ( 32066663) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intraocular pressure ( 30054594 29785010 29617998 29235454 24002674 31959993) Keratoconus ( 33649486) Longevity ( 30294719) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 17903305) Red vs. brown/black hair color ( 30531825) Refractive error ( 32231278) Response to fenofibrate (triglyceride levels) ( 27002377) Tea consumption ( 31046077) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197) Weight loss (gastric bypass surgery) ( 23633212)	Height ( 18391951)
Interacting Genes		1 interacting genes: CAMLG	21 interacting genes: ADIPOQ AGR2 BCL2L13 EGFR ETNK1 F11R GET1 HSP90B1 HSPA13 KCNE4 LAT LCN2 OCIAD1 PBXIP1 PGRMC1 PKHD1 PPIB TMEM31 TNFRSF13B TXNDC12 VWC2
Entrez ID		5314	819
HPRD ID		05987	03073
Ensembl ID		ENSG00000170927	ENSG00000164615
Uniprot IDs		P08F94	P49069
PDB IDs			6SO5 8CR1
Enriched GO Terms of Interacting Partners?		Prostaglandin-I Synthase Activity B Cell Homeostasis Protein Insertion Into ER Membrane GET Complex Endoplasmic Reticulum Membrane Receptor Recycling Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Execution Phase Of Apoptosis Decidualization Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Purine-containing Compound Salvage Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway NAD+ Biosynthetic Process Response To Interleukin-6 Pyridine Nucleotide Biosynthetic Process Hydroperoxy Icosatetraenoate Dehydratase Activity NAD+ Biosynthetic Process Via The Salvage Pathway Purine Nucleotide Salvage Cellular Response To Interleukin-6 Prostaglandin Metabolic Process Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Prostanoid Metabolic Process NAD+ Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Receptor Metabolic Process Embryo Implantation Cellular Response To Interleukin-1 Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Lymphocyte Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Endoplasmic Reticulum Protein Insertion Into Membrane Caveola Negative Regulation Of Protein Ubiquitination ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Leukocyte Homeostasis Response To Interleukin-1 Negative Regulation Of Post-translational Protein Modification Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process	Endoplasmic Reticulum Localization Within Membrane Positive Regulation Of Protein Localization To Plasma Membrane Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Protein Localization To Membrane Protein Localization To Cell Periphery Digestive Tract Morphogenesis Protein-containing Complex Smooth Endoplasmic Reticulum Regulation Of Protein Localization To Plasma Membrane Regulation Of Cellular Localization Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Localization To Membrane
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