POU4F2 and LCE2C

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		POU4F2	LCE2C
Description		POU class 4 homeobox 2	late cornified envelope 2C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Promoter-specific Chromatin Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Axonogenesis Axon Guidance Heart Development Sensory Perception Of Sound Cell Differentiation Neuron Differentiation Estrogen Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Cellular Response To Insulin Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Axon Extension Neuromuscular Process Controlling Balance Regulation Of DNA-binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Adipose Tissue Development Dorsal Root Ganglion Development Positive Regulation Of Transcription Regulatory Region DNA Binding	Epidermis Development Keratinization
Pathways		Regulation of TP53 Activity through Association with Co-factors	Formation of the cornified envelope
Drugs
Diseases
GWAS		Malaria ( 31844061) Metabolite levels ( 23823483)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		77 interacting genes: ADAMTSL4 ALPP CCN3 CD46 CERCAM CHIC2 CHRD CHRDL2 COL8A1 CYP21A2 CYSRT1 DLX3 ESR1 FAM86C1P GRN HDHD3 HIGD2B IGFBP6 IGFL1 INCA1 KPRP KRT31 KRT35 KRT38 KRT83 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1C LCE1F LCE2C LCE5A LCN2 LGALS13 LHX2 LYPD2 MMADHC NFKBID NOTO PCSK5 PLSCR2 RBP3 RBPMS RGS19 SPRY4 TGFB1 TRIM42 VWC2	87 interacting genes: ADAMTSL4 ALPP C1orf94 CATSPER1 CCDC125 CHIC2 CRCT1 CREB5 CYP21A2 CYSRT1 EFEMP1 EFEMP2 EFNA3 FAM221B HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2D LCE3A LCE3B LCE3D LCE4A LCE5A MACO1 NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUFIP2 OTX1 PCSK5 PIAS2 POU4F2 PTPMT1 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRY1 TAP1 TGFB1 TM7SF2 TRIM42 UBE2I VASN VWC2 XAGE3
Entrez ID		5458	353140
HPRD ID		00220	13972
Ensembl ID		ENSG00000151615	ENSG00000187180
Uniprot IDs		Q12837	Q5TA81
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Keratinization Protein Binding Cytosol Structural Constituent Of Skin Epidermis Identical Protein Binding	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding
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