POU4F2 and DLX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POU4F2	DLX3
Description		POU class 4 homeobox 2	distal-less homeobox 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Axonogenesis Axon Guidance Heart Development Sensory Perception Of Sound Cell Differentiation Neuron Differentiation Estrogen Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Cellular Response To Insulin Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Axon Extension Neuromuscular Process Controlling Balance Regulation Of DNA-binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Adipose Tissue Development Dorsal Root Ganglion Development Positive Regulation Of Transcription Regulatory Region DNA Binding	Blood Vessel Development Placenta Development Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gene Expression Wnt Signaling Pathway BMP Signaling Pathway Epithelial Cell Differentiation Hair Follicle Morphogenesis Hair Cell Differentiation Odontogenesis Of Dentin-containing Tooth Hair Cycle Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Hair Follicle Cell Proliferation Odontoblast Differentiation
Pathways		Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases			Trichodentoosseous dysplasia Amelogenesis imperfecta hypoplastic-hypomaturation with taurodontism (AIHHT)
GWAS		Malaria ( 31844061) Metabolite levels ( 23823483)	Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)
Interacting Genes		77 interacting genes: ADAMTSL4 ALPP CCN3 CD46 CERCAM CHIC2 CHRD CHRDL2 COL8A1 CYP21A2 CYSRT1 DLX3 ESR1 FAM86C1P GRN HDHD3 HIGD2B IGFBP6 IGFL1 INCA1 KPRP KRT31 KRT35 KRT38 KRT83 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1C LCE1F LCE2C LCE5A LCN2 LGALS13 LHX2 LYPD2 MMADHC NFKBID NOTO PCSK5 PLSCR2 RBP3 RBPMS RGS19 SPRY4 TGFB1 TRIM42 VWC2	5 interacting genes: BANP POU4F2 PRKCA TBL1X TDP2
Entrez ID		5458	1747
HPRD ID		00220	02752
Ensembl ID		ENSG00000151615	ENSG00000064195
Uniprot IDs		Q12837	O60479
PDB IDs			4XRS
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Keratinization Protein Binding Cytosol Structural Constituent Of Skin Epidermis Identical Protein Binding	Response To Estradiol Nucleoplasm Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Amacrine Cell Differentiation Axonogenesis Sensory Perception Of Mechanical Stimulus Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Myeloid Cell Differentiation Sensory Perception Of Sound Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Leukocyte Differentiation Negative Regulation Of Biosynthetic Process Nervous System Process Dorsal Root Ganglion Development Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase C Signaling Transcription Corepressor Activity Regulation Of Myeloid Cell Differentiation Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Desmosome Assembly Positive Regulation Of Nervous System Development Negative Regulation Of Adipose Tissue Development Neuron Projection Morphogenesis Negative Regulation Of Macromolecule Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Metabolic Process Positive Regulation Of Transcription Regulatory Region DNA Binding Response To Peptide Hormone Apoptotic Signaling Pathway Regulation Of Axon Guidance Mitotic Nuclear Membrane Disassembly Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Phorbol 13-acetate 12-myristate Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Bone Resorption Diacylglycerol Binding Ganglion Development Desmosome Organization Positive Regulation Of Macrophage Differentiation
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