ADAMTS12 and MYL6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ADAMTS12	MYL6
Gene Name		ADAM metallopeptidase with thrombospondin type 1 motif, 12	myosin, light chain 6, alkali, smooth muscle and non-muscle
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Matrix	Cytosol Membrane Myosin Complex Unconventional Myosin Complex Vesicle Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding	Motor Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Actin-dependent ATPase Activity
	Biological Process	Cell-matrix Adhesion Cell Migration Proteoglycan Catabolic Process Negative Regulation Of Chondrocyte Differentiation Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To BMP Stimulus Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus	Muscle Contraction Axon Guidance Skeletal Muscle Tissue Development Metabolic Process Muscle Filament Sliding Ephrin Receptor Signaling Pathway
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation	EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions Smooth Muscle Contraction EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Mortality among heart failure patients ( 20400778) Stroke (pediatric) ( 22990015)
Protein-Protein Interactions		3 interactors: CALM2 MEOX2 MYL6	7 interactors: ADAMTS12 DNAJB9 EWSR1 GLP1R MLH1 MOB4 NUDT21
Entrez ID		81792	4637
HPRD ID		05862	17618
Ensembl ID		ENSG00000151388	ENSG00000092841
Uniprot IDs		P58397	B7Z6Z4 F8VZU9 G3V1Y7 P60660 Q6IBG5
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Muscle Contraction Muscle System Process Muscle Organ Development Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Striated Muscle Tissue Development Muscle Tissue Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of High Voltage-gated Calcium Channel Activity Somite Specification Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Muscle Structure Development Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Organ Development Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Segment Specification Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Dephosphorylation Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Positive Regulation Of Phosphatase Activity Actin-myosin Filament Sliding Response To Corticosterone Muscle Filament Sliding Positive Regulation Of Cation Channel Activity Enzyme Linked Receptor Protein Signaling Pathway Response To Amphetamine	MRNA 3'-end Processing Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus Meiotic Spindle Midzone Assembly Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Meiotic Metaphase I Plate Congression RNA 3'-end Processing Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Mitotic Recombination Proteoglycan Catabolic Process Regulation Of Mitotic Recombination Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Male Meiosis Chromosome Segregation Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Spindle Midzone Assembly
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