ADAMTS12

Gene Name		ADAM metallopeptidase with thrombospondin type 1 motif, 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Cell-matrix Adhesion Cell Migration Proteoglycan Catabolic Process Negative Regulation Of Chondrocyte Differentiation Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To BMP Stimulus Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
Drugs
Diseases
GWAS		Mortality among heart failure patients ( 20400778) Stroke (pediatric) ( 22990015)
Protein-protein Interactions		3 interactors: CALM2 MEOX2 MYL6
Entrez ID		81792
HPRD ID		05862
Ensembl ID		ENSG00000151388
Uniprot IDs		P58397
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Muscle Contraction Muscle System Process Muscle Organ Development Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Striated Muscle Tissue Development Muscle Tissue Development Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of High Voltage-gated Calcium Channel Activity Somite Specification Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Muscle Structure Development Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Organ Development Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Segment Specification Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Peptidyl-threonine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Dephosphorylation Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Positive Regulation Of Phosphatase Activity Actin-myosin Filament Sliding Response To Corticosterone Muscle Filament Sliding Positive Regulation Of Cation Channel Activity Enzyme Linked Receptor Protein Signaling Pathway Response To Amphetamine
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