PLA2G12A and RPS6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PLA2G12A	RPS6
Gene Name		phospholipase A2, group XIIA	ribosomal protein S6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Golgi Apparatus	Nucleus Nucleolus Cytoplasm Cytosol Polysome Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Calcium-dependent Phospholipase A2 Activity	Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Biological_process Lipid Catabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process	Ribosomal Small Subunit Assembly G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Placenta Development T Cell Proliferation Involved In Immune Response RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Activation-induced Cell Death Of T Cells Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Gastrulation Insulin Receptor Signaling Pathway Gene Expression Viral Process Viral Life Cycle Viral Transcription Oogenesis Stage TOR Signaling T Cell Differentiation In Thymus Ribosomal Small Subunit Biogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Erythrocyte Development
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS	Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling Peptide chain elongation IGF1R signaling cascade Influenza Life Cycle Formation of the ternary complex, and subsequently, the 43S complex IRS-related events triggered by IGF1R Influenza Viral RNA Transcription and Replication Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Insulin receptor signalling cascade Translation SRP-dependent cotranslational protein targeting to membrane S6K1 signalling Eukaryotic Translation Termination IRS-related events Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits PKB-mediated events Eukaryotic Translation Elongation PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: DVL2 MEF2C RB1 RPS15 RPS6 TMEM37 UCK1 UMPS YWHAG	12 interactors: ATF4 NDRG1 OLFM2 PAK2 PLA2G12A PRKACB PRKCSH RPS4X RPS6KB1 RPS6KB2 STAU1 UPF2
Entrez ID		81579	6194
HPRD ID		17858	01592
Ensembl ID		ENSG00000123739	ENSG00000137154
Uniprot IDs		Q542Y6 Q9BZM1	A2A3R5 A2A3R6 P62753
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		Ribosomal Small Subunit Assembly UMP Biosynthetic Process Ribosome Assembly Cellular Protein Localization Cellular Localization Homeostasis Of Number Of Cells Pyrimidine Nucleobase Metabolic Process Myeloid Cell Differentiation Ribosomal Small Subunit Biogenesis Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Pyrimidine Ribonucleotide Biosynthetic Process Regulation Of Kinase Activity Pyrimidine Nucleoside Biosynthetic Process Cellular Response To Drug Pyrimidine Nucleotide Biosynthetic Process Outflow Tract Morphogenesis Nucleobase-containing Compound Metabolic Process Lymphocyte Homeostasis Intracellular Signal Transduction Apoptotic Process Pyrimidine Nucleoside Metabolic Process Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Programmed Cell Death Pyrimidine Nucleotide Metabolic Process Cell Death Death Regulation Of Protein Phosphorylation Organelle Localization Protein Targeting Leukocyte Homeostasis Cellular Nitrogen Compound Metabolic Process Viral Transcription Ribonucleoside Monophosphate Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cellular Response To Organonitrogen Compound Organelle Assembly Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Nucleoside Monophosphate Biosynthetic Process Erythrocyte Differentiation Protein Localization To Organelle Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Primary Heart Field Specification	Positive Regulation Of Translation Positive Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Translational Initiation Protein Kinase B Signaling Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Translation Response To Glucagon Regulation Of Protein Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Innate Immune Response Response To Stress Response To Clozapine Regulation Of Translational Initiation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Growth Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Positive Regulation Of Kinase Activity Phosphatidylinositol-mediated Signaling Cellular Protein Metabolic Process Glucose Metabolic Process Positive Regulation Of Transferase Activity Skeletal Muscle Atrophy Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Nuclear-transcribed MRNA Catabolic Process RNA Localization Liver Development Carbohydrate Biosynthetic Process Cellular Response To Growth Factor Stimulus Immune System Process MRNA Catabolic Process Striated Muscle Atrophy Response To Leucine Immune Response Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Phosphorylation Defense Response Muscle Atrophy
Tagcloud ?			acidified autophagy basally chloroquine chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic mtorc1 nelfinavir normalised s6k1 signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1
Tagcloud (Difference) ?			acidified autophagy basally chloroquine chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic mtorc1 nelfinavir normalised s6k1 signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1
Tagcloud (Intersection) ?