TMX1 and DNAAF2

		TMX1	DNAAF2
Description		thioredoxin related transmembrane protein 1	dynein axonemal assembly factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane Mitochondrial Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site	Extracellular Region Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Cilium Ciliary Basal Body Protein Folding Chaperone Complex Dynein Axonemal Particle
	Molecular Function	Protein Disulfide Isomerase Activity Enzyme Inhibitor Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity	Protein Binding
	Biological Process	Negative Regulation Of Triglyceride Biosynthetic Process Triglyceride Biosynthetic Process Response To Endoplasmic Reticulum Stress Regulation Of Calcium Ion Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of ERAD Pathway	In Utero Embryonic Development Epithelial Cilium Movement Involved In Extracellular Fluid Movement Response To Retinoic Acid Outer Dynein Arm Assembly Inner Dynein Arm Assembly Protein Stabilization Establishment Of Localization In Cell Cilium-dependent Cell Motility Establishment Of Left/right Asymmetry Axonemal Dynein Complex Assembly
Pathways
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Cancer ( 29299148) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)	Carotid intima media thickness ( 26343869)
Interacting Genes		12 interacting genes: BCL2L2 CCR1 CDC42 FAS FKBP8 GET3 GIMAP1 GIMAP5 LHFPL5 PMP22 SPI1 SULT2A1	3 interacting genes: APP HMGB1 RNF10
Entrez ID		81542	55172
HPRD ID		15590	12627
Ensembl ID		ENSG00000139921	ENSG00000165506
Uniprot IDs		Q9H3N1	Q9NVR5
PDB IDs		1X5E
Enriched GO Terms of Interacting Partners?			RAGE Receptor Binding Positive Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Positive Regulation Of Interleukin-1 Production Growth Cone Lamellipodium Positive Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Chemoattractant Activity Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Chemotaxis Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Monocyte Chemotaxis Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Endoplasmic Reticulum Subcompartment 2-hydroxyglutarate Dehydrogenase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mononuclear Cell Migration Regulation Of Chemokine Production Regulation Of Interleukin-1 Production Regulation Of Type II Interferon Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Receptor Ligand Activity Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Myeloid Leukocyte Activation Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Nervous System Process Microglia Development
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