DNAAF2

Description		dynein axonemal assembly factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Cilium Ciliary Basal Body Protein Folding Chaperone Complex Dynein Axonemal Particle
	Molecular Function	Protein Binding
	Biological Process	In Utero Embryonic Development Epithelial Cilium Movement Involved In Extracellular Fluid Movement Response To Retinoic Acid Outer Dynein Arm Assembly Inner Dynein Arm Assembly Protein Stabilization Establishment Of Localization In Cell Cilium-dependent Cell Motility Establishment Of Left/right Asymmetry Axonemal Dynein Complex Assembly
Pathways
Drugs
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Carotid intima media thickness ( 26343869)
Novel Interacting Genes		4 novel interacting genes: ATL1 L2HGDH TMX1 TRIM9
Interacting Genes		3 interacting genes: APP HMGB1 RNF10
Entrez ID		55172
HPRD ID		12627
Ensembl ID		ENSG00000165506
Uniprot IDs		Q9NVR5
PDB IDs
Enriched GO Terms of Interacting Partners?		RAGE Receptor Binding Positive Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Positive Regulation Of Interleukin-1 Production Growth Cone Lamellipodium Positive Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Chemoattractant Activity Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Chemotaxis Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Monocyte Chemotaxis Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Endoplasmic Reticulum Subcompartment 2-hydroxyglutarate Dehydrogenase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mononuclear Cell Migration Regulation Of Chemokine Production Regulation Of Interleukin-1 Production Regulation Of Type II Interferon Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Receptor Ligand Activity Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Myeloid Leukocyte Activation Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Nervous System Process Microglia Development
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