FRMD3 and PLPP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FRMD3	PLPP4
Description		FERM domain containing 3	phospholipid phosphatase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding Cytoskeletal Protein Binding	Diacylglycerol Diphosphate Phosphatase Activity Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Actomyosin Structure Organization	Blastocyst Hatching Lipid Metabolic Process Phospholipid Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phospholipid Dephosphorylation Regulation Of Calcium Ion Import
Pathways			Role of phospholipids in phagocytosis
Drugs
Diseases
GWAS		Blood pressure traits (multi-trait analysis) ( 28498854) Hypertension ( 28498854) Insulin sensitivity index ( 24699409) Lewy body disease ( 25188341) Loneliness (multivariate analysis) ( 27629369) Metabolite levels ( 23823483)	Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		12 interacting genes: CMTM7 CYB5B JAGN1 NRM PLPP4 SERP1 SERP2 SLC35A4 TMEM201 TMEM218 TMEM97 ZFPL1	33 interacting genes: ANKRD46 ARL13B BCL2L13 BIK BMP10 CD74 CISD2 CPLX4 CREB3L1 CYB5B ERGIC3 EVI2A FAM209A FRMD3 GET1 GJA1 GJB5 GPX8 LMNA LRRC59 MGST3 PAGE1 PDZK1IP1 PSCA SGPL1 SLC35A1 SSMEM1 STX1A STX2 SYT2 TMEM139 TMEM45B UPK1B
Entrez ID		257019	196051
HPRD ID		07402	18745
Ensembl ID		ENSG00000172159	ENSG00000203805
Uniprot IDs		A2A2Y4	Q5VZY2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Nuclear Membrane Nuclear Inner Membrane Protein Localization To Extracellular Region Hormone Secretion Insulin Secretion Peptide Hormone Secretion Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Hormone Transport Endoplasmic Reticulum Unfolded Protein Response Establishment Of Protein Localization To Extracellular Region Protein Secretion Regulation Of Protein Transport Peptide Transport Peptide Secretion Positive Regulation Of Lipoprotein Transport Nitric-oxide Synthase Complex Nitrite Reductase (NO-forming) Activity Granulocyte Colony-stimulating Factor Signaling Pathway B-1a B Cell Differentiation B-1 B Cell Differentiation Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Diacylglycerol Diphosphate Phosphatase Activity Nuclear Migration Along Microtubule	Membrane SNARE Binding Endoplasmic Reticulum Membrane SNARE Complex Ventricular Cardiac Muscle Cell Development
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