TAS2R10 and PDCD1LG2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TAS2R10	PDCD1LG2
Name		taste 2 receptor member 10	programmed cell death 1 ligand 2
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Endomembrane System Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Taste Receptor Activity Bitter Taste Receptor Activity	Protein Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Taste	Adaptive Immune Response Immune System Process Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Cellular Response To Lipopolysaccharide
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste	Co-inhibition by PD-1 PD-L1(CD274) glycosylation and translocation to plasma membrane
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 ) Serum alkaline phosphatase levels ( 33339817 )
Novel Interactors		None recorded	1 novel interactors: EXOSC8
Interacting Genes		4 interacting genes: HERPUD2 PDCD1LG2 RTP4 SSMEM1	20 interacting genes: ATP6V0C ERMP1 GALNT15 GPR37L1 KTN1 LRP10 MFSD6 PDCD1 RUSF1 SLC35H1 SLC38A1 SLC38A7 SLC41A2 SLC7A1 SMIM3 TAS2R10 TMEM147 TMEM218 TMEM239 TMEM97
Entrez ID		50839	80380
HPRD ID		11990	16147
Ensembl ID		ENSG00000121318	ENSG00000197646
Uniprot IDs		Q9NYW0	Q9BQ51
PDB IDs		Not available	6UMT 8J3V
GO Terms Enriched among Interactors		None	Membrane Glutamine Transport L-glutamine Transmembrane Transporter Activity Amino Acid Transmembrane Transport Amino Acid Transport