GRPEL1 and GALT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRPEL1	GALT
Description		GrpE like 1, mitochondrial	galactose-1-phosphate uridylyltransferase
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GO Annotations	Cellular Component	PAM Complex, Tim23 Associated Import Motor Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix	Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Unfolded Protein Binding Protein-folding Chaperone Binding	Protein Binding UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding
	Biological Process	Protein Folding Intracellular Protein Transport Protein Import Into Mitochondrial Matrix	UDP-alpha-D-glucose Metabolic Process Galactose Metabolic Process Phosphate-containing Compound Metabolic Process Organophosphate Metabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Carbohydrate Derivative Metabolic Process
Pathways		Mitochondrial protein import	Defective GALT can cause GALCT Galactose catabolism
Drugs
Diseases			Galactosemia
GWAS		Eosinophil percentage of white cells ( 32888494)
Interacting Genes		7 interacting genes: CCDC57 ERCC6 GALT ISG15 POLR1C SPG21 WBP2	6 interacting genes: GRPEL1 KRTAP6-2 NQO1 TNK2 TRIP13 VAC14
Entrez ID		80273	2592
HPRD ID		07550	06106
Ensembl ID		ENSG00000109519	ENSG00000213930
Uniprot IDs		Q9HAV7	A0A0S2Z3Y7 B2RAT6 P07902
PDB IDs		9BLS 9BLT 9BLU	5IN3 6GQD
Enriched GO Terms of Interacting Partners?			Regulation Of Receptor-mediated Endocytosis CCR7 Chemokine Receptor Binding Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Establishment Of T Cell Polarity Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Endocytosis Chemokine Receptor Binding Immunological Synapse Formation Identical Protein Binding Dendritic Cell Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Eosinophil Chemotaxis Positive Regulation Of Glycoprotein Metabolic Process Cell Maturation Eosinophil Migration Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Response To Prostaglandin E Positive Regulation Of Granulocyte Chemotaxis Cellular Response To Prostaglandin Stimulus CCR Chemokine Receptor Binding Regulation Of Vesicle-mediated Transport Positive Regulation Of Neutrophil Migration Developmental Maturation Regulation Of Neutrophil Chemotaxis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Neutrophil Migration T Cell Costimulation Chemokine Activity Regulation Of Granulocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Leukocyte Apoptotic Process Cell-cell Recognition Negative Regulation Of Sequestering Of Calcium Ion NADH Dehydrogenase (quinone) (non-electrogenic) Activity Positive Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly PAS Complex Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Granulocyte Migration Establishment Of Cell Polarity Positive Regulation Of Leukocyte Chemotaxis
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