GRPEL1 and DSP

		GRPEL1	DSP
Description		GrpE like 1, mitochondrial	desmoplakin
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GO Annotations	Cellular Component	PAM Complex, Tim23 Associated Import Motor Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Mitochondrial Matrix	Cornified Envelope Nucleus Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Unfolded Protein Binding Protein-folding Chaperone Binding	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding
	Biological Process	Protein Folding Intracellular Protein Transport Protein Import Into Mitochondrial Matrix	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Adherens Junction Organization Wound Healing Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Protein Localization To Cell-cell Junction
Pathways		Mitochondrial protein import	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND1 GTPase cycle
Drugs			Zinc Artenimol Zinc acetate
Diseases			Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Eosinophil percentage of white cells ( 32888494)	Chronic obstructive pulmonary disease ( 28166215 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Idiopathic pulmonary fibrosis ( 29066090 31710517) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) PR interval ( 32439900) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)
Interacting Genes		7 interacting genes: CCDC57 ERCC6 GALT ISG15 POLR1C SPG21 WBP2	36 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDC42 CDH5 COL17A1 COPS6 DES DSC1 ENO3 EVPL H19 IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN RNF10 TTC3 UCHL5 USP7 VIM WEE2-AS1
Entrez ID		80273	1832
HPRD ID		07550	00513
Ensembl ID		ENSG00000109519	ENSG00000096696
Uniprot IDs		Q9HAV7	A0AAQ5BH43 B4DKX6 P15924
PDB IDs		9BLS 9BLT 9BLU	1LM5 1LM7 3R6N 5DZZ
Enriched GO Terms of Interacting Partners?			Cornified Envelope Desmosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Cysteine-type Endopeptidase Activity Cell-cell Junction Organization Desmosome Organization Cell Junction Assembly Intermediate Filament Organization Cysteine-type Peptidase Activity Cell-cell Junction Anchoring Junction Desmosome Assembly Cell Junction Organization Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Assembly Cytoplasm Peptidase Activity Keratinization Alpha-catenin Binding Adherens Junction Intermediate Filament Cytoskeleton Cadherin Binding Desmosome Maintenance Cytoskeleton Organization Cytosol Peptide Cross-linking Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Cell-cell Adhesion Cell Adhesion Epidermis Development Cellular Component Assembly Positive Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Execution Phase Of Apoptosis Proteolysis Cellular Response To Staurosporine Protein Metabolic Process Protein Processing Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Protein Maturation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Periphery Response To Indole-3-methanol Cell Junction Structural Constituent Of Cytoskeleton Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
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