FBXO11 and BCL6

Number of citations of the paper that reports this interaction (PMID 22113614)
29

Data Source:
BioGRID (enzymatic study)

		FBXO11	BCL6
Gene Name		F-box protein 11	B-cell CLL/lymphoma 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Chromosome Nucleolus Cytoplasm	Nucleus Replication Fork
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-arginine N-methyltransferase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Sound Protein Ubiquitination Peptidyl-arginine N-methylation	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Negative Regulation Of Cell-matrix Adhesion Germinal Center Formation Regulation Of Germinal Center Formation Negative Regulation Of B Cell Apoptotic Process Transcription, DNA-templated Inflammatory Response Cellular Response To DNA Damage Stimulus Rho Protein Signal Transduction Spermatogenesis Negative Regulation Of Cell Proliferation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Histone Deacetylation Regulation Of Rho GTPase Activity Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response Positive Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Negative Regulation Of Cellular Senescence
Pathways
Drugs
Diseases
GWAS		Schizophrenia ( 23894747)	B cell non-Hodgkin lymphoma ( 23749188) PR interval ( 23534349) Pulmonary function (interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727)
Protein-Protein Interactions		5 interactors: BCL6 HDAC6 SKP1 TP53 USP16	44 interactors: AES BCL11A BCL6B BCOR BLZF1 CDK19 CDK8 CHD3 CREBBP CUTC EP300 FBXO11 HDAC4 HDAC5 HDAC7 HDAC9 IRF4 JUN JUNB JUND KIFC3 LIMS3 MAPK1 MED17 MED6 MTA3 NCOR1 NCOR2 PELI1 PIN1 PML PPARD PRKD3 RAF1 RUNX1T1 SIAH1 SIN3A SP1 SPI1 TRAF1 WNK4 ZBTB16 ZBTB7A ZBTB7B
Entrez ID		80204	604
HPRD ID		06985	00180
Ensembl ID		ENSG00000138081	ENSG00000113916
Uniprot IDs		Q86XK2	B5B0A5 P41182
PDB IDs			1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ
Enriched GO Terms of Interacting Partners?		Chromatin Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Histone Deacetylation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Deacetylation Protein Import Into Nucleus, Translocation Positive Regulation Of Cellular Metabolic Process Chromosome Organization Regulation Of Histone Deacetylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Deacetylation Histone Modification Organelle Organization Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Histone Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Programmed Cell Death Chromatin Modification Negative Regulation Of DNA Metabolic Process Protein Catabolic Process Positive Regulation Of Cell Death B Cell Differentiation Protein Tetramerization Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Regulation Of Proteolysis Mitotic Cell Cycle Process Protein Import Into Nucleus Nuclear Import Regulation Of Histone Modification Mitotic Cell Cycle Cellular Response To Starvation Notch Signaling Pathway Negative Regulation Of Macromitophagy Positive Regulation Of Chaperone-mediated Protein Complex Assembly Oligodendrocyte Apoptotic Process Polyubiquitinated Misfolded Protein Transport Regulation Of Reactive Oxygen Species Metabolic Process Protein Import B Cell Activation Transcription, DNA-templated Negative Regulation Of Cell Growth Cellular Response To DNA Damage Stimulus	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated RNA Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Hemopoiesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Immune System Development Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Immune System Process DNA-templated Transcription, Initiation Response To Organic Substance Leukocyte Differentiation Chromatin Modification Cellular Protein Modification Process Developmental Process Nitrogen Compound Metabolic Process Organ Development Chromosome Organization
Tagcloud ?		21kd accumulating acts anticipated bcl6 box correlates cul1 inversely ligase microrna mir mirna normally oncogene oncogenic promotes proteosomal rescue restored skp1 subfamily suppress suppressor suppressors tumorigenesis tumorigenicity ubiquitination unifying	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Difference) ?		21kd accumulating acts anticipated box correlates cul1 inversely ligase microrna mir mirna normally oncogene oncogenic promotes proteosomal rescue restored skp1 subfamily suppress suppressor suppressors tumorigenesis tumorigenicity ubiquitination unifying	ablated conducive cor corepressors deacteylases erbaalpha erbbeta interactiondomains laz3 locks mad mxi physicalassociation rev rid rids rip13a rip13delta1 rpd3 rvr sin3 sin3a sin3b tafii32 tafii70 tafs terminalrepression tfiib zip
Tagcloud (Intersection) ?		bcl6