FBXO11

Description		F-box protein 11
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-arginine N-methyltransferase Activity Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Sound Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Asthma ( 27611488) Chronotype ( 30696823) Cortical surface area ( 32963231) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Macular thickness ( 30535121) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 23894747)
Interacting Genes		8 interacting genes: BAHD1 BCL6 CFTR DSCR9 HDAC6 HNRNPA2B1 TP53 USP16
Entrez ID		80204
HPRD ID		06985
Ensembl ID		ENSG00000138081
Uniprot IDs		A0A804HK63 Q86XK2
PDB IDs		5VMD
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Epigenetic Regulation Of Gene Expression Chromatin Organization Negative Regulation Of Cell Growth Negative Regulation Of DNA Replication Negative Regulation Of Gene Expression, Epigenetic Replication Fork 14-3-3 Protein Binding Negative Regulation Of Growth Negative Regulation Of Macroautophagy Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Senescence Regulation Of Lymphocyte Apoptotic Process Cellular Response To Stress Transcription Corepressor Binding Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Cell Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Molecular Condensate Scaffold Activity Regulation Of Mitophagy Negative Regulation Of Helicase Activity Regulation Of Autophagy Of Mitochondrion Negative Regulation Of G1 To G0 Transition Mitophagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis T Cell Activation Involved In Immune Response Autophagy Of Mitochondrion Regulation Of DNA Metabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Lymphocyte Activation Involved In Immune Response Negative Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of DNA Replication Negative Regulation Of Mast Cell Cytokine Production Isotype Switching To IgE Isotypes Mononuclear Cell Proliferation Regulation Of Cell Growth Chromatin Binding Lymphocyte Proliferation Negative Regulation Of Plasma Cell Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein-folding Chaperone Binding Enzyme Binding Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport
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