PTGES2 and CRY2

		PTGES2	CRY2
Description		prostaglandin E synthase 2	cryptochrome circadian regulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck Cry-Per Complex
	Molecular Function	DNA Binding Protein Binding Lyase Activity Isomerase Activity Heme Binding 12-hydroxyheptadecatrienoic Acid Synthase Activity Glutathione Binding Prostaglandin-E Synthase Activity	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Phosphatase Inhibitor Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding FAD Binding
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Positive Regulation Of DNA-templated Transcription Prostanoid Biosynthetic Process Secretion	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Protein Import Into Nucleus Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Response To Insulin Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Neutrophil degranulation	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins
Drugs
Diseases		Penile cancer
GWAS		Body mass index ( 26426971)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Glycemic traits (pleiotropy) ( 31021400) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)
Interacting Genes		6 interacting genes: ADRB2 CEBPB CFAP141 EXOSC10 HSPA13 PTGFR	53 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 CYSRT1 DELEC1 EZH2 FBXL21P FBXL3 KLHL6 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP19-6 KRTAP4-2 KRTAP5-1 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-8 LMNA MID1 MTUS2 NADK NBPF19 NOTCH2NLA NPAS2 PDE9A PER1 PER2 PER3 PICK1 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGER4 SBK3 SDCBP2 STK11 TIMELESS TRAF1 TRAF2 TTC1 VWC2 XRN2 ZBTB42
Entrez ID		80142	1408
HPRD ID		07458	07226
Ensembl ID		ENSG00000148334	ENSG00000121671
Uniprot IDs		A0A7I2V5X6 A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7	A0A0D2X7Z3 A2I2P1 Q49AN0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Sodium-dependent Phosphate Transport Regulation Of Phosphate Transport Brown Fat Cell Differentiation Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential Photoreactive Repair Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Prostaglandin F Receptor Activity Beta2-adrenergic Receptor Activity Granuloma Formation C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis T-helper 1 Cell Activation Kinase Binding CHOP-C/EBP Complex Positive Regulation Of Sodium-dependent Phosphate Transport Cry-Per Complex Regulation Of Homologous Chromosome Segregation U5 SnRNA Binding Norepinephrine Binding Negative Regulation Of Glucocorticoid Secretion Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Response To Psychosocial Stress Fat Cell Differentiation Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway SnRNA Catabolic Process CUT Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagosome Maturation Regulation Of Cold-induced Thermogenesis Heat Generation Nucleic Acid Metabolic Process Hepatocyte Proliferation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Blue Light Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway	Intermediate Filament Photoperiodism Regulation Of Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Keratin Filament Entrainment Of Circadian Clock Cytosol Circadian Regulation Of Gene Expression Circadian Rhythm Transcription Corepressor Binding Identical Protein Binding Response To Light Stimulus Response To Radiation Protein Phosphatase Type 2A Complex CLOCK-BMAL Transcription Complex Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Binding Protein Phosphatase Regulator Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Thioesterase Binding Meiotic Sister Chromatid Cohesion E-box Binding Response To Redox State G1 To G0 Transition
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