SIX3 and TLE3

Number of citations of the paper that reports this interaction (PubMedID 12441302)
0

Data Source:
HPRD (two hybrid, in vitro)

		SIX3	TLE3
Description		SIX homeobox 3	TLE family member 3, transcriptional corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Brain Development Visual Perception Gonad Development Proximal/distal Axis Specification Neuroblast Differentiation Diencephalon Development Telencephalon Development Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Thyroid Gland Development Multicellular Organism Growth Regulation Of Cell Population Proliferation Camera-type Eye Development Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Circadian Behavior Lens Induction In Camera-type Eye Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis
Pathways			Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
Drugs
Diseases		Holoprosencephaly (HPE)
GWAS		Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Alcohol and nicotine co-dependence ( 22488850) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol use disorder ( 30940813) Blood sugar levels ( 29403010) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Clozapine-induced myocarditis in schizophrenia ( 32066683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fasting blood glucose ( 29621232 33842983) Fasting glucose ( 34059833) Fasting plasma glucose ( 25187374) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General risk tolerance (MTAG) ( 30643258) Glycated hemoglobin levels ( 29170429 34059833) Hemoglobin A1c levels ( 29403010) Intraocular pressure ( 30054594 29785010 31959993) Irritable mood ( 29500382) Lung cancer ( 28604730) Metabolite levels ( 21909109) Myopia ( 27182965) Optic disc size ( 31809533) Problematic alcohol use ( 32451486) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Self-reported risk-taking behaviour ( 30271922) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 32499647)	Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340 28552196 25282103) Hip circumference adjusted for BMI ( 34021172) L-selectin levels ( 25576479) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Monocyte percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 32439900 30046033) Pulmonary function ( 23932459) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Schizophrenia ( 30285260 29483656 25056061) Serum total protein levels ( 29403010) Triglyceride levels ( 29403010 33339817) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: EYA1 GMNN NR4A3 OTUD3 PAX6 TLE1 TLE3 TLE5	17 interacting genes: APP CHERP CSTF2 FBXO7 FOXG1 H2AC1 H3C1 H4C1 HINFP KRTAP15-1 NDRG1 NOTCH1 PIN1 SIX1 SIX3 TCF4 USP47
Entrez ID		6496	7090
HPRD ID		04756	02558
Ensembl ID		ENSG00000138083	ENSG00000140332
Uniprot IDs		O95343	B3KUA2 H0YL70 Q04726 Q6PRX3
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Animal Organ Morphogenesis Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Semicircular Canal Morphogenesis Negative Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Beta-catenin-TCF Complex Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Anoikis Histone Acetyltransferase Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Metabolic Process Wnt Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Inner Ear Morphogenesis Regulation Of Wnt Signaling Pathway Negative Regulation Of Metabolic Process Nucleus Otic Vesicle Morphogenesis Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Energy Homeostasis Regulation Of Epithelial Cell Proliferation Cell Fate Specification Embryonic Morphogenesis Positive Regulation Of Monocyte Aggregation Vestibular Reflex Developmental Process Histone H2AXY142 Phosphatase Activity Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Habenula Development	Protein Heterodimerization Activity Regulation Of Neuron Differentiation Nucleus Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Axon Midline Choice Point Recognition Regulation Of Neuroblast Proliferation Regulation Of Cell Cycle Process Axon Choice Point Recognition Regulation Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Regulation Of Cardioblast Proliferation Establishment Of Protein Localization To Organelle Mitogen-activated Protein Kinase Kinase Binding Apoptotic Process Nucleoplasm Negative Regulation Of Neuron Differentiation Cell Death Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Protein Targeting Structural Constituent Of Chromatin Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neuron Differentiation Regulation Of Neural Precursor Cell Proliferation Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Notch Signaling Pathway Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Cycle Process Epithelial Cell Maturation Nucleosome Cellular Developmental Process Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Survivin Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of RNA Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Cell Maturation Positive Regulation Of Toll Signaling Pathway
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