SIX3 and TLE3

Number of citations of the paper that reports this interaction (PMID 12441302)
36

Data Source:
HPRD (in vitro, two hybrid)

		SIX3	TLE3
Gene Name		SIX homeobox 3	transducin-like enhancer of split 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Corepressor Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Histone Deacetylase Binding	Protein Binding
	Biological Process	Protein Import Into Nucleus, Translocation Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Transcription From RNA Polymerase II Promoter Brain Development Visual Perception Proximal/distal Axis Specification Neuroblast Differentiation Telencephalon Development Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Circadian Behavior Lens Induction In Camera-type Eye Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Organ Morphogenesis Wnt Signaling Pathway
Pathways			APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS		Alcohol and nictotine co-dependence ( 22488850) Metabolite levels ( 21909109)	Height ( 20881960)
Protein-Protein Interactions		7 interactors: AES EYA1 GMNN NR4A3 PAX6 TLE1 TLE3	6 interactors: APP FOXG1 HINFP NDRG1 PIN1 SIX3
Entrez ID		6496	7090
HPRD ID		04756	02558
Ensembl ID		ENSG00000138083	ENSG00000140332
Uniprot IDs		O95343	H0YL70 Q04726
PDB IDs
Enriched GO Terms of Interacting Partners?		Organ Morphogenesis Anatomical Structure Morphogenesis Organ Development Semicircular Canal Morphogenesis System Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Semicircular Canal Development RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Anoikis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Neuron Fate Specification Developmental Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Wnt Signaling Pathway Establishment Of Mitotic Spindle Orientation Gene Expression Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Cellular Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Macromolecule Biosynthetic Process Spindle Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Fate Commitment Embryonic Organ Development Negative Regulation Of Gene Expression Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Cell Fate Specification Inner Ear Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Apoptotic Process Establishment Of Cell Polarity Sensory Organ Development	Regulation Of Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Neuroblast Migration Optic Vesicle Morphogenesis Synaptic Growth At Neuromuscular Junction Cell Maturation Brain Development Head Development Collateral Sprouting In Absence Of Injury Regulation Of Neural Retina Development Lens Fiber Cell Apoptotic Process Neuroblast Differentiation Negative Regulation Of Neuron Differentiation Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Proximal/distal Axis Specification Central Nervous System Development Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Multicellular Organismal Development Positive Regulation Of Spindle Checkpoint Axon Choice Point Recognition Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Positive Regulation Of Cell Cycle Negative Regulation Of Neurogenesis Neuron Remodeling Forebrain Dorsal/ventral Pattern Formation Lens Induction In Camera-type Eye Positive Regulation Of Cell Cycle Checkpoint Negative Regulation Of Cell Development Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Developmental Process Telencephalon Regionalization RNA Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Circadian Behavior Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Rhythmic Behavior
Tagcloud ?		accompany acetyltransferases alphaa alphab aphakia cbp conditional crystallins discontinuation ectoderm ectodermal embryologic fate integral k18 k27 k27me3 k4me3 k9ac lens organogenesis pax6 placode posttranslational prone sox2 specification subtly unaltered	ablated adaptive adipocytes adipose concomitantly fed genetically glut4 hfd homeostatic improves irs knockout linchpin mature message mimicked peroxisome ppargamma preferentially proliferator qrt rosiglitazone s6k1 sc split subcutaneous t2d transducin
Tagcloud (Difference) ?		accompany acetyltransferases alphaa alphab aphakia cbp conditional crystallins discontinuation ectoderm ectodermal embryologic fate integral k18 k27 k27me3 k4me3 k9ac lens organogenesis pax6 placode posttranslational prone sox2 specification subtly unaltered	ablated adaptive adipocytes adipose concomitantly fed genetically glut4 hfd homeostatic improves irs knockout linchpin mature message mimicked peroxisome ppargamma preferentially proliferator qrt rosiglitazone s6k1 sc split subcutaneous t2d transducin
Tagcloud (Intersection) ?