SIX3

Name	SIX homeobox 3
Structure	No pdb structure
Interactors	8 interactors: EYA1 GMNN NR4A3 OTUD3 PAX6 TLE1 TLE3 TLE5
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Brain Development Visual Perception Gonad Development Proximal/distal Axis Specification Neuroblast Differentiation Diencephalon Development Telencephalon Development Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Thyroid Gland Development Multicellular Organism Growth Regulation Of Cell Population Proliferation Camera-type Eye Development Negative Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Circadian Behavior Lens Induction In Camera-type Eye Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation
Diseases	Holoprosencephaly (HPE)
GWAS	Adventurousness ( 30643258 ) Age at first sexual intercourse ( 34211149 ) Alcohol and nicotine co-dependence ( 22488850 ) Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30679032 30643258 ) Alcohol use disorder ( 30940813 ) Blood sugar levels ( 29403010 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Clozapine-induced myocarditis in schizophrenia ( 32066683 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Fasting blood glucose ( 29621232 33842983 ) Fasting glucose ( 34059833 ) Fasting plasma glucose ( 25187374 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) General risk tolerance (MTAG) ( 30643258 ) Glycated hemoglobin levels ( 29170429 34059833 ) Hemoglobin A1c levels ( 29403010 ) Intraocular pressure ( 30054594 29785010 31959993 ) Irritable mood ( 29500382 ) Lung cancer ( 28604730 ) Metabolite levels ( 21909109 ) Myopia ( 27182965 ) Optic disc size ( 31809533 ) Problematic alcohol use ( 32451486 ) Refractive error ( 32231278 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Self-reported risk-taking behaviour ( 30271922 ) Smoking behaviour (cigarette pack-years) ( 30679032 ) Smoking initiation ( 30617275 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes ( 32499647 )
Entrez ID	6496
HPRD ID	04756
Ensembl ID	ENSG00000138083
Uniprot IDs	O95343
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Animal Organ Morphogenesis Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Semicircular Canal Morphogenesis Negative Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Beta-catenin-TCF Complex Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Anoikis Histone Acetyltransferase Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Regulation Of Metabolic Process Wnt Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Inner Ear Morphogenesis Regulation Of Wnt Signaling Pathway Negative Regulation Of Metabolic Process Nucleus Otic Vesicle Morphogenesis Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Energy Homeostasis Regulation Of Epithelial Cell Proliferation Cell Fate Specification Embryonic Morphogenesis Positive Regulation Of Monocyte Aggregation Vestibular Reflex Developmental Process Histone H2AXY142 Phosphatase Activity Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Habenula Development