UBTD1 and FZD5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		UBTD1	FZD5
Gene Name		ubiquitin domain containing 1	frizzled class receptor 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Golgi Membrane Plasma Membrane Tight Junction Cell Surface Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function		G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process		Embryonic Axis Specification Angiogenesis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Tight Junction Assembly
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: BCOR CD1A FZD5 KIAA2026 MID1 MID2 MRFAP1L1 PFKM RANBP2 RNF10 TEAD1 TRIM39 UBE2D4	11 interactors: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 UBTD1 WNT5A WNT7A
Entrez ID		80019	7855
HPRD ID		08568	03427
Ensembl ID		ENSG00000165886	ENSG00000163251
Uniprot IDs		Q9HAC8	Q13467
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Localization To Microtubule Protein Localization To Cytoskeleton Negative Regulation Of Histone H3-K36 Methylation Negative Regulation Of Tooth Mineralization Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Pattern Specification Process Axis Specification Depurination Regulation Of Chorionic Trophoblast Cell Proliferation Spemann Organizer Formation Protein Localization To Organelle Cellular Protein Modification Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Signal Transduction Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Specification Of Axis Polarity Negative Regulation Of Odontogenesis Negative Regulation Of Glucokinase Activity Positive Regulation Of Stem Cell Maintenance DNA Dealkylation Involved In DNA Repair Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Histone H3-K4 Methylation Base-excision Repair, AP Site Formation Chorionic Trophoblast Cell Differentiation Protein K6-linked Ubiquitination Glucose Homeostasis Chorion Development Pathogenesis Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Myelination Regulation Of Tight Junction Assembly Negative Regulation Of Glial Cell Proliferation Post-embryonic Camera-type Eye Development Fructose 6-phosphate Metabolic Process Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Intracellular Signal Transduction Histone H2A Monoubiquitination Regulation Of Metabolic Process Lateral Mesoderm Development Cardiovascular System Development Negative Regulation Of Viral Release From Host Cell Histone H2A Ubiquitination	Regulation Of Canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Embryonic Development Non-canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt Signaling Pathway Cartilage Development Pericardium Morphogenesis Epithelial To Mesenchymal Transition Genitalia Development Negative Regulation Of Signal Transduction Morphogenesis Of An Epithelial Sheet Connective Tissue Development Stem Cell Development Negative Regulation Of Signaling Regulation Of MAPK Cascade Single Organism Reproductive Process Embryonic Digit Morphogenesis Sex Differentiation Regulation Of Phosphorylation Somitogenesis Reproductive Process Developmental Process Involved In Reproduction Stem Cell Differentiation Embryonic Pattern Specification Cell Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Somite Development Primitive Streak Formation Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorus Metabolic Process Palate Development Regulation Of Embryonic Development Axis Specification Segmentation Mesenchymal Cell Development Negative Regulation Of Phosphorylation Convergent Extension Positive Regulation Of Peptidyl-threonine Phosphorylation Uterus Development Mesenchymal Cell Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Dopaminergic Neuron Differentiation Forebrain Development Central Nervous System Development
Tagcloud ?		attenuation barrier besides britain constitutes copyright correlates creates damageing depend depends feedback great impacts ireland john ltd mdm2 mutually passageing premature senescence serial society sons transformed tumourigenesis wiley worse	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Difference) ?		attenuation barrier besides britain constitutes copyright correlates creates damageing depend depends feedback great impacts ireland john ltd mdm2 mutually passageing premature senescence serial society sons transformed tumourigenesis wiley worse	aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd8 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring
Tagcloud (Intersection) ?