ANKRD53 and LZTR1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ANKRD53	LZTR1
Description		ankyrin repeat domain 53	leucine zipper like post translational regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Spindle Cytoskeleton	Endosome Golgi Apparatus Endomembrane System Membrane Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Mitotic Metaphase Chromosome Alignment Positive Regulation Of Microtubule Polymerization Cell Division Regulation Of Mitotic Spindle Organization Regulation Of Mitotic Cytokinesis	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: BCL6 GLYCTK LZTR1	54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		79998	8216
HPRD ID		07762	08992
Ensembl ID		ENSG00000144031	ENSG00000099949
Uniprot IDs		C9JZ61 Q8N9V6	A0A384NL67 Q8N653
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mast Cell Cytokine Production Isotype Switching To IgE Isotypes Negative Regulation Of Plasma Cell Differentiation Golgi Apparatus Intronic Transcription Regulatory Region Sequence-specific DNA Binding Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Glycerate Kinase Activity Negative Regulation Of Isotype Switching Negative Regulation Of T-helper 2 Cell Differentiation Pyramidal Neuron Differentiation Regulation Of Small GTPase Mediated Signal Transduction Plasma Cell Differentiation Negative Regulation Of B Cell Differentiation Regulation Of Germinal Center Formation Paraspeckles T-helper 2 Cell Differentiation Type 2 Immune Response Germinal Center Formation Negative Regulation Of Immunoglobulin Production Negative Regulation Of DNA-templated DNA Replication Regulation Of Memory T Cell Differentiation Glyceraldehyde-3-phosphate Metabolic Process Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of B Cell Apoptotic Process Fructose Metabolic Process Negative Regulation Of Type 2 Immune Response Regulation Of B Cell Apoptotic Process Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Regulatory T Cell Differentiation Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Negative Regulation Of DNA Replication Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of T-helper Cell Differentiation Isotype Switching Negative Regulation Of Cellular Senescence Negative Regulation Of Ras Protein Signal Transduction Somatic Diversification Of Immunoglobulins Involved In Immune Response Mature B Cell Differentiation Involved In Immune Response Replication Fork T-helper Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Mature B Cell Differentiation B Cell Proliferation Regulation Of Isotype Switching Negative Regulation Of Cell-matrix Adhesion	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nuclear Body Nucleic Acid Metabolic Process Nucleolus Ribonucleoside Binding Transcription Coactivator Activity Chromatin Organization RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex DNA-directed RNA Polymerase Activity Regulation Of DNA-templated Transcription Initiation Chromo Shadow Domain Binding Chromatin Remodeling 5'-3' RNA Polymerase Activity
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