OBFC1 and LDLRAP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OBFC1	LDLRAP1
Gene Name		oligonucleotide/oligosaccharide-binding fold containing 1	low density lipoprotein receptor adaptor protein 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton Stn1-Ten1 Complex	Early Endosome Cytosol Neurofilament Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane AP-1 Adaptor Complex AP-2 Adaptor Complex Axon Recycling Endosome
	Molecular Function	Single-stranded DNA Binding Protein Binding Single-stranded Telomeric DNA Binding	Beta-amyloid Binding Phosphotyrosine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Receptor Signaling Complex Scaffold Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Positive Regulation Of DNA Replication	Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Positive Regulation Of Signal Transduction Receptor Internalization Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process
Pathways
Drugs
Diseases
GWAS		Endothelial function traits ( 17903301) Interstitial lung disease ( 23583980) Telomere length ( 23535734 20421499 23001564) Uterine fibroids ( 21460842)	Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)
Protein-Protein Interactions		6 interactors: APP LDLRAP1 MVP TPP1 TUBGCP4 ZDHHC17	7 interactors: AP2B1 APP CLTC LDLR LRP2 OBFC1 TFAP2A
Entrez ID		79991	26119
HPRD ID		14872	05765
Ensembl ID			ENSG00000157978
Uniprot IDs		Q9H668	B3KR97 Q5SW96
PDB IDs		4JOI 4JQF	2G30
Enriched GO Terms of Interacting Partners?		Regulation Of Binding Regulation Of Protein Tyrosine Kinase Activity Neuromuscular Process Controlling Balance Negative Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Single-stranded Telomeric DNA Binding Cholesterol Metabolic Process Sterol Metabolic Process Neuromuscular Process Regulation Of Establishment Of Blood-brain Barrier Synaptic Growth At Neuromuscular Junction Regulation Of Protein Kinase Activity Regulation Of Protein Binding Regulation Of Kinase Activity Collateral Sprouting In Absence Of Injury Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Intermembrane Transport Chemical Homeostasis Vitamin E Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Protection From Non-homologous End Joining At Telomere Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Axon Choice Point Recognition Positive Regulation Of Telomerase Activity Telomere Assembly Regulation Of Protein Phosphorylation Steroid Metabolic Process Transport Neuron Remodeling Positive Regulation Of Cholesterol Metabolic Process Intracellular Cholesterol Transport Intracellular Sterol Transport Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Lipid Metabolic Process Negative Regulation Of Cell Development Regulation Of Phosphorylation Negative Regulation Of Protein Autophosphorylation Alcohol Metabolic Process Peptide Catabolic Process Protein Metabolic Process Homeostatic Process Regulation Of Signaling Protein Transport Regulation Of Telomerase Activity Regulation Of Cellular Amino Acid Metabolic Process	Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Receptor-mediated Endocytosis Vesicle-mediated Transport Steroid Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Response To Light Stimulus Alcohol Metabolic Process Phototransduction, Visible Light Forebrain Development Response To Radiation Retinoid Metabolic Process Diterpenoid Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Detection Of Visible Light Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Optic Cup Structural Organization Phototransduction Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Optic Vesicle Morphogenesis Oculomotor Nerve Formation Synaptic Growth At Neuromuscular Junction Sterol Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Collateral Sprouting In Absence Of Injury Positive Regulation Of Tooth Mineralization Negative Regulation Of Hyaluronan Biosynthetic Process Response To External Stimulus Brain Development Detection Of Abiotic Stimulus Oculomotor Nerve Development Head Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Neuron Development Central Nervous System Development Intestinal Cholesterol Absorption Anterior Neuropore Closure Nervous System Development Optic Cup Morphogenesis Involved In Camera-type Eye Development
Tagcloud ?		aa ac ages biology cardiovascular caucasian cc cvd disequilibrium enrolled estimate etiologic genotyped hr insight intervals leukocyte linkage ltl minor polymorphisms rs3772190 rs4387287 rs9419958 similarly snps telomere terc trend
Tagcloud (Difference) ?		aa ac ages biology cardiovascular caucasian cc cvd disequilibrium enrolled estimate etiologic genotyped hr insight intervals leukocyte linkage ltl minor polymorphisms rs3772190 rs4387287 rs9419958 similarly snps telomere terc trend
Tagcloud (Intersection) ?