WDR76 and DCAF8

Number of citations of the paper that reports this interaction (PubMedID 33288900)
75

Data Source:
BioGRID (pull down)

		WDR76	DCAF8
Description		WD repeat domain 76	DDB1 and CUL4 associated factor 8
Image		No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Site Of DNA Damage	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Protein Binding Enzyme Binding	Protein Binding
	Biological Process	DNA Damage Response Regulation Of DNA Damage Checkpoint	Myotube Cell Development Protein Ubiquitination
Pathways			Neddylation
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Serum albumin levels ( 23022100)	Breast size ( 27182965) Lung function (FEV1/FVC) ( 30061609) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		3 interacting genes: DCAF8 KRAS NRAS	17 interacting genes: CRYAA DDB1 GSK3A GTPBP3 MDFI PIK3R3 PRMT1 PRMT8 RAF1 RBM11 RBPMS SPAST SUV39H1 THAP1 TNS2 TRIM54 WDR76
Entrez ID		79968	50717
HPRD ID		07804	18300
Ensembl ID		ENSG00000092470	ENSG00000132716
Uniprot IDs		A0A0C4DFX7 Q9H967	B7Z8C9 Q5TAQ9
PDB IDs			3I8E
Enriched GO Terms of Interacting Partners?		GDP Binding G Protein Activity Ras Protein Signal Transduction Response To Isolation Stress Small GTPase-mediated Signal Transduction GMP Binding Forebrain Astrocyte Development MAPK Cascade LRR Domain Binding GTPase Activity Response To Gravity Protein-containing Complex Binding GTP Binding Type I Pneumocyte Differentiation Myoblast Proliferation Cardiac Muscle Cell Proliferation Lung Epithelial Cell Differentiation Positive Regulation Of Cellular Senescence Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Glial Cell Proliferation Astrocyte Development Glial Cell Proliferation Golgi Membrane Lung Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Long-term Neuronal Synaptic Plasticity Cul4-RING E3 Ubiquitin Ligase Complex Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Protein-membrane Adaptor Activity Myotube Cell Development Response To Mineralocorticoid Homeostasis Of Number Of Cells Within A Tissue Regulation Of Glial Cell Proliferation Intracellular Signaling Cassette Cell Development Muscle Cell Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cellular Senescence Negative Regulation Of Epithelial Cell Differentiation Visual Learning Visual Behavior Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Gliogenesis Endoplasmic Reticulum Membrane Skeletal Muscle Cell Differentiation Glial Cell Development Tertiary Granule Membrane Striated Muscle Cell Differentiation	Epigenetic Programming Of Gene Expression Protein-arginine Omega-N Monomethyltransferase Activity Histone Methyltransferase Activity Peptidyl-arginine Methylation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Methylation Insulin Receptor Signaling Pathway Epigenetic Programming In The Zygotic Pronuclei Identical Protein Binding Nucleus S-adenosyl-L-methionine Binding Macromolecule Methylation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Viral Protein Processing S-adenosylmethionine-dependent Methyltransferase Activity Viral Process Developmental Process Regulation Of Microtubule Cytoskeleton Organization Enzyme Binding Protein Methylation Methyltransferase Activity Regulation Of Microtubule Depolymerization Cellular Developmental Process Protein-containing Complex Assembly Negative Regulation Of UDP-glucose Catabolic Process Cell Differentiation Protein Homooligomerization GATOR1 Complex Binding Chromatin Organization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus RNA Processing Regulation Of Macromolecule Metabolic Process Heterochromatin Response To Stress Protein-containing Complex Organization Negative Regulation Of Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Complex Oligomerization Death-inducing Signaling Complex Assembly TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Regulation Of Microtubule-based Process Regulation Of Alternative MRNA Splicing, Via Spliceosome
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