ERMP1 and MLANA

		ERMP1	MLANA
Description		endoplasmic reticulum metallopeptidase 1	melan-A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Melanosome Membrane Melanosome
	Molecular Function	Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	Proteolysis Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress
Pathways			Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Blond vs. brown/black hair color ( 30531825) Waist-hip ratio ( 28552196)	Asthma ( 31619474 31959851) Hippocampal volume in mild cognitive impairment ( 29274321) Multiple sclerosis ( 22190364)
Interacting Genes		39 interacting genes: AQP2 AQP6 ATP1B4 BCL2L13 BSCL2 CD200R1 CLDN5 CLDN7 CLDN9 CLEC2D CREB3L1 ERVFRD-1 FAM209A FKBP7 FNDC9 GJA8 GPR42 GPRC5D HHLA2 HIBADH IER3IP1 IFNGR2 KCNN3 KLRC1 LYPD5 MR1 PDCD1LG2 PEX12 RHCG SLC13A4 SLC18A1 SLC22A23 SLC23A2 SLC7A14 SPAG4 SSMEM1 TMEM237 TMEM45A TMEM80	4 interacting genes: EPN2 ITCH NEDD4 YAP1
Entrez ID		79956	2315
HPRD ID		17227	09269
Ensembl ID		ENSG00000099219	ENSG00000120215
Uniprot IDs		A0A8I5KNY4 A0A8I5KXJ0 E7ER77 Q6ZMD3 Q7Z2K6	A0A384MR46 Q16655
PDB IDs			2GT9 2GTW 2GTZ 2GUO 3HG1 3L6F 3MRO 3MRP 3MRQ 3QDM 3QEQ 3QFD 4EUP 4JFF 4L3E 4QOK 4WJ5 5E9D 5NHT 5NQK 6D78 6DKP 6TMO 7Q9B 7TR4
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Plasma Membrane Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Transmembrane Transporter Activity Protein Binding Renal Water Transport Bicellular Tight Junction Assembly External Side Of Plasma Membrane Ammonium Channel Activity Ammonium Transmembrane Transport Tight Junction Assembly Nuclear Inner Membrane Tight Junction Organization Amine Transport Water Channel Activity Carbon Dioxide Transport Structural Molecule Activity	Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Proline-rich Region Binding Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Signal Transduction Receptor Internalization Mesenchyme Development Endocytosis Negative Regulation Of Cell Communication Protein K63-linked Ubiquitination Negative Regulation Of Signaling Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Regulation Of Notch Signaling Pathway Regulation Of Stem Cell Differentiation Enterocyte Differentiation Import Into Cell Intracellular Signal Transduction Negative Regulation Of Cellular Response To Growth Factor Stimulus Channel Inhibitor Activity Cell Cortex Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Cellular Response To Radiation Phosphothreonine Residue Binding Receptor-mediated Endocytosis Lateral Mesoderm Development TEAD-YAP Complex Cardiac Muscle Tissue Regeneration T Cell Anergy Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Positive Regulation Of Protein Catabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Developmental Process Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of T Cell Anergy CXCL12-activated CXCR4 Signaling Pathway T Cell Tolerance Induction Bud Elongation Involved In Lung Branching C-X-C Chemokine Receptor CXCR4 Signaling Pathway Sodium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Paraxial Mesoderm Development Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Regulation Of T Cell Anergy Tube Morphogenesis Protein Polyubiquitination Regulation Of Cellular Response To Growth Factor Stimulus
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