BTNL8 and CLDN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BTNL8	CLDN5
Description		butyrophilin like 8	claudin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Paranode Region Of Axon Schmidt-Lanterman Incisure Tight Junction Anchoring Junction
	Molecular Function	Signaling Receptor Binding Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cytokine Production Adaptive Immune Response Immune System Process T Cell Receptor Signaling Pathway	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Myelination Negative Regulation Of Vascular Permeability Response To Ethanol Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier
Pathways		Butyrophilin (BTN) family interactions	Tight junction interactions RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		5 interacting genes: CLDN5 HHLA2 IFNGR2 MILR1 TFF1	40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1
Entrez ID		79908	7122
HPRD ID		12549	03654
Ensembl ID		ENSG00000113303	ENSG00000184113
Uniprot IDs		Q6UX41	D3DX19 O00501
PDB IDs
Enriched GO Terms of Interacting Partners?			Membrane
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