GEMIN7 and GEMIN6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		GEMIN7	GEMIN6
Description		gem nuclear organelle associated protein 7	gem nuclear organelle associated protein 6
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies Sm-like Protein Family Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies
	Molecular Function	RNA Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal fluid AB1-42 levels ( 28247064)
Interacting Genes		20 interacting genes: ADD1 CEP126 EDRF1 FEZ1 GEMIN6 GOLM1 KAT5 RN7SL1 RNU1-1 RNU2-1 RPLP1 SHC1 SMN1 SNRPB SNRPD2 SNRPD3 SNRPE STRAP TAOK1 TUBA1A	16 interacting genes: ACOT11 DDIT4L GEMIN7 NUFIP1 RASL11B RN7SL1 RNU1-1 RNU2-1 SNRPB SNRPD2 SNRPD3 SNRPE SNRPF SNRPG STRAP TOX4
Entrez ID		79760	79833
HPRD ID		07600	06110
Ensembl ID		ENSG00000142252	ENSG00000152147
Uniprot IDs		Q9H840	Q8WXD5
PDB IDs		1Y96 7BBL	1Y96 7BBL
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly Protein-RNA Complex Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation U4 SnRNP Methylosome Small Nuclear Ribonucleoprotein Complex RNA Splicing, Via Transesterification Reactions U1 SnRNP U5 SnRNP U2-type Prespliceosome Assembly U12-type Spliceosomal Complex PICln-Sm Protein Complex U2-type Spliceosomal Complex Cellular Component Assembly U2-type Catalytic Step 2 Spliceosome Protein-containing Complex Assembly U7 SnRNP MRNA Splicing, Via Spliceosome U4/U6 X U5 Tri-snRNP Complex RNA Splicing Protein-containing Complex Organization SMN Complex U2-type Precatalytic Spliceosome MRNA Processing U2 SnRNP Binding Precatalytic Spliceosome RNA Methylation Telomerase Holoenzyme Complex Catalytic Step 2 Spliceosome MRNA Metabolic Process Histone Pre-mRNA DCP Binding Macromolecule Methylation RNA Modification RNA Processing Spliceosomal Complex Nuclear Body Ribonucleoprotein Complex Gemini Of Cajal Bodies Methylation Protein Targeting To Vacuole Involved In Autophagy RNA Binding Nucleic Acid Metabolic Process Telomerase RNA Binding Negative Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Cytosol Protein Methylation	SMN-Sm Protein Complex 7-methylguanosine Cap Hypermethylation Spliceosomal SnRNP Assembly U2 SnRNP U4 SnRNP Methylosome Protein-RNA Complex Assembly Small Nuclear Ribonucleoprotein Complex U1 SnRNP U7 SnRNP U5 SnRNP U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions PICln-Sm Protein Complex RNA Methylation Catalytic Step 2 Spliceosome RNA Splicing Macromolecule Methylation Protein-containing Complex Assembly MRNA Processing Precatalytic Spliceosome Protein-containing Complex Organization RNA Modification Spliceosomal Complex RNA Processing Methylation MRNA Metabolic Process Ribonucleoprotein Complex U2 SnRNP Binding Cellular Component Assembly Telomerase Holoenzyme Complex RNA Metabolic Process RNA Binding Histone Pre-mRNA DCP Binding Spliceosomal Tri-snRNP Complex Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process SMN Complex U2-type Prespliceosome Telomerase RNA Binding Protein Methylation Pre-mRNA Branch Point Binding MRNA Branch Site Recognition
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