GIPC2 and FZD3

Number of citations of the paper that reports this interaction (PMID 12011974)
23

Data Source:
HPRD (in vivo)

		GIPC2	FZD3
Gene Name		GIPC PDZ domain containing family, member 2	frizzled class receptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Dendrite Neuronal Cell Body Presynaptic Active Zone
	Molecular Function	Molecular_function	G-protein Coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity
	Biological Process	Biological_process	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Hair Follicle Development Positive Regulation Of Neuroblast Proliferation G-protein Coupled Receptor Signaling Pathway Neuron Differentiation Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Inner Ear Morphogenesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Canonical Wnt Signaling Pathway Sympathetic Ganglion Development Commissural Neuron Axon Guidance Negative Regulation Of Execution Phase Of Apoptosis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Ca2+ pathway Asymmetric localization of PCP proteins Signaling by Wnt Metabolic disorders of biological oxidation enzymes GPCR ligand binding PCP/CE pathway Class B/2 (Secretin family receptors) beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		7 interactors: FZD3 IGSF21 PTN SETDB1 SP100 UNC119 ZBTB26	3 interactors: GIPC1 GIPC2 GIPC3
Entrez ID		54810	7976
HPRD ID		17040	05849
Ensembl ID			ENSG00000104290
Uniprot IDs		Q8TF65	A8K615 Q9NPG1
PDB IDs		3GGE
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-mediated Endocytosis Cell Proliferation In Midbrain Negative Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Fas Signaling Pathway Cytokinesis, Completion Of Separation Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Protein Export From Nucleus Regulation Of Caveolin-mediated Endocytosis Learning Or Memory Mitotic Cytokinetic Process Negative Regulation Of Execution Phase Of Apoptosis Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Neurological System Process Cognition Histone H3-K9 Trimethylation	Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cytokinesis Acid Secretion Regulation Of Cytokinesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Endothelial Cell Migration Dicarboxylic Acid Transport Epithelial Cell Migration Epithelium Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Positive Regulation Of Cell Division Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc1 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	adds arealization axon axons barrel celsr2 celsr3 conditional contexts forebrain guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly vangl vangl1 vangl2 wiring
Tagcloud (Difference) ?		adrb1 alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc1 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3	adds arealization axon axons barrel celsr2 celsr3 conditional contexts forebrain guidance guidepost inactivation mimics navigation pcp perturbs planar polarity projections redundantly thalamic thalamocortical thalamus unexpectedly vangl vangl1 wiring
Tagcloud (Intersection) ?		vangl2