GIPC2 and FZD3

Number of citations: 0 (PubMedID 12011974)
Data Source: HPRD (in vivo)

		GIPC2	FZD3
Name		GIPC PDZ domain containing family member 2	frizzled class receptor 3
Structure
GO Annotations	Cellular Component	Cytoplasm Extracellular Exosome	Cytoplasm Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Dendrite Filopodium Tip Neuronal Cell Body Apical Part Of Cell Presynaptic Active Zone Presynaptic Active Zone Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity
	Biological Process	None	Establishment Of Planar Polarity Neural Tube Closure Hair Follicle Development Positive Regulation Of Neuroblast Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Response To Xenobiotic Stimulus Wnt Signaling Pathway Neuron Differentiation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Inner Ear Morphogenesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Response To Electrical Stimulus Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Sympathetic Ganglion Development Commissural Neuron Axon Guidance Motor Neuron Migration Negative Regulation Of Execution Phase Of Apoptosis Midbrain Morphogenesis
Pathways		None	Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Asymmetric localization of PCP proteins
GWAS		Age at first birth ( 34211149 ) Body mass index ( 29273807 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) End-stage kidney disease ( 31178898 ) Hand grip strength ( 29691431 ) Height ( 20881960 25282103 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference ( 25673412 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Platelet distribution width ( 32888494 ) Post bronchodilator FEV1 ( 26634245 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Severe influenza A (H1N1) infection ( 26379185 )	No GWAS studies recorded
Interacting Genes		14 interacting genes: CTRC FZD3 IGSF21 IRF4 LZTS2 PATJ PLEKHA2 PTN SETDB1 SP100 UBE2I UNC119 ZBTB26 ZCCHC7	3 interacting genes: GIPC1 GIPC2 GIPC3
Entrez ID		54810	7976
HPRD ID		17040	05849
Ensembl ID		ENSG00000137960	ENSG00000104290
Uniprot IDs		A0A384P5H2 Q8TF65	Q9NPG1
PDB IDs		3GGE	8JHC 8JHI 8Q7O 8QW4
GO Terms Enriched among Interactors		None	Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Transmission, Glutamatergic Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Vesicle Membrane Glutamatergic Synapse Cell-cell Signaling Cell Communication Signaling Synaptic Vesicle Chloride:proton Antiporter Activity Positive Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Synaptic Plasticity Locomotory Behavior G Protein-coupled Adenosine Receptor Activity Type 5 Metabotropic Glutamate Receptor Binding Negative Regulation Of Cell Volume Volume-sensitive Chloride Channel Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Norepinephrine Secretion Synaptic Transmission, Dopaminergic Prepulse Inhibition Inhibitory Postsynaptic Potential Positive Regulation Of Urine Volume Asymmetric Synapse Positive Regulation Of Glutamate Secretion Axolemma Alpha-actinin Binding Response To Caffeine G Protein-coupled Adenosine Receptor Signaling Pathway Specific Granule Endosomal Lumen Acidification Voltage-gated Chloride Channel Activity Cellular Response To Interleukin-7 Regulation Of Melanin Biosynthetic Process Response To Interleukin-7 Positive Regulation Of Melanin Biosynthetic Process Glutamate Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Circadian Rhythm Regulation Of Urine Volume Astrocyte Activation Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Vascular Permeability Chloride Transmembrane Transporter Activity