SPRR2F and KCTD17

Data Source: HiPPIP (Novel)

		SPRR2F	KCTD17
Name		small proline rich protein 2F	potassium channel tetramerization domain containing 17
Structure		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	None	Protein Binding Identical Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Epidermis Development Keratinocyte Differentiation Keratinization	Cell Projection Organization Endoplasmic Reticulum Calcium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cilium Assembly Protein Homooligomerization
Pathways		Formation of the cornified envelope	None
GWAS		Asthma ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 )	Hemoglobin levels ( 33491795 ) Iron status biomarkers (ferritin levels) ( 28334935 ) Liver iron content ( 34128465 ) Mean corpuscular hemoglobin concentration ( 28453575 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet distribution width ( 32888494 ) Red blood cell traits ( 23222517 )
Novel Interactors		1 novel interactors: KCTD17	4 novel interactors: ARL8A EGR2 SPHK1 SPRR2F
Interacting Genes		None recorded	23 interacting genes: AQP1 CRK DMC1 FARS2 LAT LNX1 LRRC18 MGAT5B NCK2 NIF3L1 NUDT18 OR51E1 PLCG2 PSMA1 RBX1 RIN3 RWDD4 STK16 SUV39H2 TCHP TINF2 TUBGCP4 UBE2D1
Entrez ID		6705	79734
HPRD ID		18699	07764
Ensembl ID		ENSG00000244094	ENSG00000100379
Uniprot IDs		Q96RM1	A0A087WX35 Q8N5Z5
PDB IDs		Not available	5A6R
GO Terms Enriched among Interactors		Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cilium Assembly Cullin Family Protein Binding	Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding