NLRX1 and SARM1

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		NLRX1	SARM1
Gene Name		NLR family member X1	sterile alpha and TIR motif containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane	Cytoplasm Mitochondrion Cytosol Microtubule Cell Junction Axon Dendrite Extrinsic Component Of Mitochondrial Outer Membrane Synapse
	Molecular Function	Protein Binding ATP Binding
	Biological Process	Viral Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Inflammatory Response	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Glucose Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Dendrite Morphogenesis Regulation Of Neuron Death
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: SARM1	7 interactors: CCDC47 GHITM IRAK2 MYD88 NLRX1 STT3A TICAM2
Entrez ID		79671	23098
HPRD ID		17640	09664
Ensembl ID		ENSG00000160703	ENSG00000004139
Uniprot IDs		Q86UT6	Q05B42 Q0D2N8 Q6SZW1
PDB IDs		3UN9
Enriched GO Terms of Interacting Partners?		MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Dendrite Morphogenesis Toll-like Receptor 4 Signaling Pathway Regulation Of Dendrite Development Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Glucose Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Response To Carbohydrate Regulation Of Innate Immune Response Regulation Of Neuron Death	Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Biotic Stimulus Innate Immune Response Lipopolysaccharide-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Chemokine Production Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Chemokine Production I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-6 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Lipid Inflammatory Response Immune Response-regulating Signaling Pathway Response To Interleukin-1 Immune Response Regulation Of Immune System Process JNK Cascade Response To Bacterium Positive Regulation Of Interleukin-18-mediated Signaling Pathway Defense Response Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Type I Interferon Production Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Co-translational Protein Modification Positive Regulation Of Immune Response
Tagcloud ?		asc card8 casp1 cd14 conceivable gc helicobacter highlighting metaplasia nlrp12 nlrp3 nlrs nod1 nod2 precancerous progresses prrs pylori rig sign tlr tlr1 tlr2 tlr3 tlr4 tlr5 tlr9 tlrs	affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic tlr toll
Tagcloud (Difference) ?		asc card8 casp1 cd14 conceivable gc helicobacter highlighting metaplasia nlrp12 nlrp3 nlrs nod1 nod2 precancerous progresses prrs pylori rig sign tlr1 tlr2 tlr3 tlr4 tlr5 tlr9 tlrs	affects allosteric ameliorates associative autism ca1 cdppb disrupt dysregulation flexibility impairs innate ltd metabotropic mglur mglur5 modulator morphogenesis neurodevelopmental nmdar players potentiation recording shank1 shank3 slice synaptic toll
Tagcloud (Intersection) ?		tlr