SKIC8 and ERRFI1

Number of citations of the paper that reports this interaction (PubMedID 20351267)
44

Data Source:
BioGRID (two hybrid)

		SKIC8	ERRFI1
Description		SKI8 subunit of superkiller complex	ERBB receptor feedback inhibitor 1
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GO Annotations	Cellular Component	Euchromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Ski Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding Kinase Binding Protein Kinase Binding Small GTPase Binding
	Biological Process	Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome	Skeletal System Development Liver Development Tissue Homeostasis Glucose Metabolic Process Lipid Metabolic Process Bile Acid Biosynthetic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Embryo Implantation Cholesterol Metabolic Process Response To Xenobiotic Stimulus Gene Expression Cell Migration Negative Regulation Of Protein Autophosphorylation Response To Estradiol Response To Progesterone Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Uterine Epithelium Development Chondrocyte Proliferation Limb Joint Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cholesterol Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Skin Development Skin Morphogenesis Regulation Of Keratinocyte Differentiation Lung Alveolus Development Response To Steroid Hormone Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Cartilage Development Uterus Development Lung Vasculature Development Lung Epithelium Development Epithelium Development Fat Pad Development Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Response To 1-oleoyl-sn-glycerol 3-phosphate
Pathways		Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Crohn's disease ( 28067908) Hair shape ( 29220522) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Morning person ( 30696823) Response to antidepressants and depression ( 27622933) Strep throat ( 28928442) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		11 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 MSRB3 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ	58 interacting genes: ACBD3 ADAM5 AGPAT4-IT1 AOX1 ARRDC5 ATM AURKA BAG4 BCAR3 CASP8 CDC42 CIAO2B COPS5 CRHBP DCTN6 EFEMP1 EGFR ERBB2 FGFR2 FGFR4 GAS1 GNPDA2 GTF2H2 HYDIN IL2RG MMP26 NEDD4 NEU1 NPC2 OSTF1 PALB2 PAPSS1 PCCA PCNA PDCD2 PHYHIPL PLEKHA3 PPIA PPM1D PSMA7 PSMB6 RAB18 RB1CC1 RUBCNL SH3YL1 SKIC8 SLC61A1 SLC7A13 SMIM30 SRC TC2N TIMP4 TM2D3 TMEM165 TMEM59 WEE1 YWHAB ZPBP
Entrez ID		80349	54206
HPRD ID		15236	09218
Ensembl ID		ENSG00000140395	ENSG00000116285
Uniprot IDs		H0YL19 Q9GZS3	B3KTV8 I6S2Y9 Q9UJM3
PDB IDs		3OW8 6GMH 6TED 7OOP 7OPC 7OPD 7QDR 7QDS 7QDY 7QDZ 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9G8O 9G8Q 9G8R	2RF9 2RFD 2RFE 4I21 4R3P 4R3R 4ZJV
Enriched GO Terms of Interacting Partners?		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Activin Receptor Signaling Pathway I-SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Pharyngeal System Development Regulation Of Metabolic Process Regulation Of Gene Expression Transforming Growth Factor Beta Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Mitotic Cell Cycle Phase Transition Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA-templated Transcription Response To Stress Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Keratinocyte Differentiation Ventricular Septum Morphogenesis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding Negative Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Endocardial Cushion Cell Fate Commitment Negative Regulation Of MRNA 3'-end Processing Hepatocyte Homeostasis Type 8 Metabotropic Glutamate Receptor Binding Engulfment Of Target By Autophagosome Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Cycle Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Epidermal Cell Differentiation Gland Development Cellular Response To Growth Factor Stimulus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Enzyme Binding ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Activity Protein Autophosphorylation Regulation Of MAPK Cascade ERBB2 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Activity Protein Phosphorylation Phosphoserine Residue Binding Kinase Activity Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Phosphorylation Protein Kinase Activity ERBB2-EGFR Signaling Pathway Cellular Response To Growth Factor Stimulus Ruffle Membrane Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of DNA Replication Positive Regulation Of DNA Biosynthetic Process Animal Organ Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Response To Estradiol Endothelin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Receptor Complex Response To Epidermal Growth Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor Progesterone Receptor Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cis-Golgi Network Membrane Cell Cycle G2/M Phase Transition DNA Repair Complex
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