OBI1 and CNOT6

Number of citations: 102 (PubMedID 34887419)
Data Source: BioGRID (pull down)

		OBI1	CNOT6
Name		ORC ubiquitin ligase 1	CCR4-NOT transcription complex subunit 6
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Chromosome	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	3'-5'-RNA Exonuclease Activity Transcription Coactivator Activity RNA Binding Catalytic Activity Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of DNA Replication Protein Monoubiquitination Protein Autoubiquitination	Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of DNA-templated Transcription Nuclear-transcribed MRNA Catabolic Process, No-go Decay
Pathways		Cyclin A/B1/B2 associated events during G2/M transition	Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
GWAS		No GWAS studies recorded	Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Ovarian cancer ( 30557369 ) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429 )
Interacting Genes		13 interacting genes: CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT6 CNOT7 CNOT9 PNKP SRPK2 TCEANC UBE2D1 UBE2D2	5 interacting genes: CNOT4 CNOT7 CNOT8 OBI1 PABPC1
Entrez ID		79596	57472
HPRD ID		12619	12341
Ensembl ID		ENSG00000152193	ENSG00000113300
Uniprot IDs		Q5W0B1	Q9ULM6
PDB IDs		Not available	7AX1
GO Terms Enriched among Interactors		CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Regulatory NcRNA-mediated Gene Silencing RNA Catabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process Poly(A)-specific Ribonuclease Activity Regulation Of Translation Macromolecule Catabolic Process Post-transcriptional Regulation Of Gene Expression RNA Metabolic Process Nucleic Acid Metabolic Process P-body Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nucleobase-containing Compound Metabolic Process Catabolic Process Macromolecule Metabolic Process Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Protein Metabolic Process Trophectodermal Cell Differentiation Negative Regulation Of Gene Expression Nucleus Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Organelle Assembly MRNA Destabilization RNA Exonuclease Activity RNA Destabilization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing	CCR4-NOT Complex Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process RNA Catabolic Process Nucleobase-containing Compound Catabolic Process CCR4-NOT Core Complex Positive Regulation Of MRNA Catabolic Process Poly(A)-specific Ribonuclease Activity Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Nucleic Acid Binding Positive Regulation Of MRNA Metabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulatory NcRNA-mediated Gene Silencing Regulation Of MRNA Stability Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of RNA Stability 3'-5'-RNA Exonuclease Activity Positive Regulation Of Viral Genome Replication MiRNA-mediated Gene Silencing By MRNA Destabilization Macromolecule Catabolic Process Regulation Of MRNA Metabolic Process Exonuclease Activity Negative Regulation Of Gene Expression Positive Regulation Of Viral Process Regulation Of Translation Protein Autoubiquitination RNA Metabolic Process Regulation Of Viral Genome Replication Cytoplasmic Ribonucleoprotein Granule RNA Binding MRNA Destabilization P-body Positive Regulation Of Catabolic Process RNA Destabilization Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of Viral Life Cycle Nuclease Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulation Of Viral Process Catabolic Process Nucleic Acid Metabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MCRD-mediated MRNA Stability Complex