OBI1 and CNOT10

Number of citations: 102 (PubMedID 34887419)
Data Source: BioGRID (pull down)

		OBI1	CNOT10
Name		ORC ubiquitin ligase 1	CCR4-NOT transcription complex subunit 10
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Chromosome	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Regulation Of DNA Replication Protein Monoubiquitination Protein Autoubiquitination	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing
Pathways		Cyclin A/B1/B2 associated events during G2/M transition	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
GWAS		No GWAS studies recorded	Diabetic retinopathy in type 2 diabetes ( 33607655 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Sensorimotor dexterity ( 31596458 )
Interacting Genes		13 interacting genes: CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT6 CNOT7 CNOT9 PNKP SRPK2 TCEANC UBE2D1 UBE2D2	4 interacting genes: CHMP1B LTB4R2 OBI1 RNF10
Entrez ID		79596	25904
HPRD ID		12619	16731
Ensembl ID		ENSG00000152193	ENSG00000182973
Uniprot IDs		Q5W0B1	Q9H9A5
PDB IDs		Not available	8BFI 8FY3
GO Terms Enriched among Interactors		CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Regulatory NcRNA-mediated Gene Silencing RNA Catabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process Poly(A)-specific Ribonuclease Activity Regulation Of Translation Macromolecule Catabolic Process Post-transcriptional Regulation Of Gene Expression RNA Metabolic Process Nucleic Acid Metabolic Process P-body Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nucleobase-containing Compound Metabolic Process Catabolic Process Macromolecule Metabolic Process Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Protein Metabolic Process Trophectodermal Cell Differentiation Negative Regulation Of Gene Expression Nucleus Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Organelle Assembly MRNA Destabilization RNA Exonuclease Activity RNA Destabilization Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing	Protein Autoubiquitination Protein Monoubiquitination Ubiquitin Protein Ligase Activity Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Leukotriene Signaling Pathway Keratinocyte Migration Negative Regulation Of Adenylate Cyclase Activity Leukotriene B4 Receptor Activity Leukotriene Receptor Activity ESCRT III Complex MIT Domain Binding Amphisome Membrane Vesicle Fusion With Vacuole ESCRT III Complex Disassembly ESCRT Complex Disassembly Viral Budding From Plasma Membrane Lysosomal Membrane Organization Multivesicular Body-lysosome Fusion Modification-dependent Protein Catabolic Process Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Ubiquitin-dependent Protein Catabolic Process Plasma Membrane Repair Mitotic Cytokinetic Process Multivesicular Body Membrane Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell Midbody Abscission Membrane Coat Protein Ubiquitination Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Epithelial Cell Migration Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation G Protein-coupled Peptide Receptor Activity Regulation Of Mitotic Spindle Organization Late Endosome To Vacuole Transport