CNOT6 and CNOT4

Number of citations of the paper that reports this interaction (PubMedID 30692204)
59

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CNOT6	CNOT4
Description		CCR4-NOT transcription complex subunit 6	CCR4-NOT transcription complex subunit 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex	Nucleus Cytoplasm Cytosol CCR4-NOT Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Transcription Coactivator Activity RNA Binding Catalytic Activity Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	Nucleic Acid Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of DNA-templated Transcription Nuclear-transcribed MRNA Catabolic Process, No-go Decay	Nuclear-transcribed MRNA Poly(A) Tail Shortening Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Megakaryocyte Differentiation Protein Autoubiquitination
Pathways		Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Ovarian cancer ( 30557369) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)	Appendicular lean mass ( 33097823) Clostridioides difficle infection ( 33841421) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Meat-related diet ( 32066663) Numerical cognitive ability ( 31620175)
Interacting Genes		5 interacting genes: CNOT4 CNOT7 CNOT8 OBI1 PABPC1	18 interacting genes: BCAS2 CNOT1 CNOT3 CNOT6 CNOT8 EP300 IL36RN KDM5C RBM15 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		57472	4850
HPRD ID		12341	05369
Ensembl ID		ENSG00000113300	ENSG00000080802
Uniprot IDs		Q9ULM6	O95628
PDB IDs		7AX1	1E4U 1UR6
Enriched GO Terms of Interacting Partners?		CCR4-NOT Complex Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process RNA Catabolic Process Nucleobase-containing Compound Catabolic Process CCR4-NOT Core Complex Positive Regulation Of MRNA Catabolic Process Poly(A)-specific Ribonuclease Activity Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Nucleic Acid Binding Positive Regulation Of MRNA Metabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulatory NcRNA-mediated Gene Silencing Regulation Of MRNA Stability Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of RNA Stability 3'-5'-RNA Exonuclease Activity Positive Regulation Of Viral Genome Replication MiRNA-mediated Gene Silencing By MRNA Destabilization Macromolecule Catabolic Process Regulation Of MRNA Metabolic Process Exonuclease Activity Negative Regulation Of Gene Expression Positive Regulation Of Viral Process Regulation Of Translation Protein Autoubiquitination RNA Metabolic Process Regulation Of Viral Genome Replication Cytoplasmic Ribonucleoprotein Granule RNA Binding MRNA Destabilization P-body Positive Regulation Of Catabolic Process RNA Destabilization Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of Viral Life Cycle Nuclease Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulation Of Viral Process Catabolic Process Nucleic Acid Metabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MCRD-mediated MRNA Stability Complex	Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Catabolic Process Protein K11-linked Ubiquitination CCR4-NOT Complex Protein Monoubiquitination Nuclear-transcribed MRNA Poly(A) Tail Shortening Protein Ubiquitination Protein Modification By Small Protein Conjugation CCR4-NOT Core Complex Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process Poly(A)-specific Ribonuclease Activity Negative Regulation Of Biosynthetic Process TORC1 Signaling Nucleus Nucleic Acid Metabolic Process Protein K63-linked Ubiquitination Protein Modification Process TOR Signaling Transferase Activity Regulation Of TORC1 Signaling ATP Binding Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulation Of TOR Signaling Nucleotide Binding Nucleobase-containing Compound Catabolic Process Regulatory NcRNA-mediated Gene Silencing Protein Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process RNA Catabolic Process Negative Regulation Of TORC1 Signaling Protein Autoubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?