PPP1R3D and EPM2A

Number of citations of the paper that reports this interaction (PMID 23624058)
1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		PPP1R3D	EPM2A
Gene Name		protein phosphatase 1, regulatory subunit 3D	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Glycogen Granule Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Polysome Plasma Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Activity Enzyme Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Carbohydrate Phosphatase Activity Starch Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Dephosphorylation	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Protein Dephosphorylation Autophagy Nervous System Development Pathogenesis Peptidyl-tyrosine Dephosphorylation Small Molecule Metabolic Process Inositol Phosphate Dephosphorylation Habituation
Pathways			Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: EPM2A PPP1CA PPP1CC	7 interactors: EPM2AIP1 NFU1 NHLRC1 PPP1R3D PRKAA1 PRKAA2 PRKAB2
Entrez ID		5509	7957
HPRD ID		04507	06345
Ensembl ID		ENSG00000132825	ENSG00000112425
Uniprot IDs		O95685 Q86X09	O95278
PDB IDs
Enriched GO Terms of Interacting Partners?		Glycogen Metabolic Process Polysaccharide Metabolic Process Energy Reserve Metabolic Process Cellular Carbohydrate Metabolic Process Protein Dephosphorylation Energy Derivation By Oxidation Of Organic Compounds Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Generation Of Precursor Metabolites And Energy Dephosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Triglyceride Metabolic Process Regulation Of Circadian Rhythm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Carbohydrate Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Circadian Rhythm Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Oxidation-reduction Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Lipid Catabolic Process Habituation Catabolic Process Rhythmic Process Nonassociative Learning Response To Light Stimulus Glycerolipid Metabolic Process Cell Division Small Molecule Metabolic Process Response To Radiation Regulation Of Glycogen Catabolic Process Inositol Phosphate Dephosphorylation Phosphorylated Carbohydrate Dephosphorylation Cellular Response To Growth Factor Stimulus Phosphate-containing Compound Metabolic Process Response To Growth Factor Cellular Protein Modification Process Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway	Regulation Of Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Regulation Of Carbohydrate Metabolic Process Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Carnitine Shuttle Generation Of Precursor Metabolites And Energy Carnitine Transmembrane Transport Carnitine Transport Regulation Of Energy Homeostasis Response To Peptide Hormone Positive Regulation Of Glycolytic Process Response To Peptide Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Cell Cycle Arrest Insulin Receptor Signaling Pathway Autophagy Quaternary Ammonium Group Transport Histone-serine Phosphorylation Oxidation-reduction Process Cellular Response To Glucose Starvation Cellular Response To Insulin Stimulus Regulation Of Glycolytic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of TOR Signaling Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Response To Organonitrogen Compound Regulation Of Glycogen Metabolic Process Long-chain Fatty Acid Transport Histone Phosphorylation Ammonium Transmembrane Transport Sterol Biosynthetic Process Regulation Of Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Anion Homeostasis Response To Hormone Fatty Acid Metabolic Process Cellular Response To Peptide Regulation Of TOR Signaling Glycogen Metabolic Process Fatty Acid Transport Ammonium Transport Negative Regulation Of Cell Cycle Polysaccharide Metabolic Process Cellular Response To Organonitrogen Compound Regulation Of Fatty Acid Metabolic Process
Tagcloud ?		allows autophagic biosynthesis dephosphorylates downregulated downregulates e3 enhancement epilepsy excess fatal glucan glycogen glycogenic interacts lafora laforin ligase malin myoclonus neuron phosphatase physically r6 recruited subunits targeting ubiquitination	arms autophago biogenesis branched chop defects disposal encode epilepsy epm2b glycogen hyperphosphorylated insoluble knock lafora laforin laforinmalin lamp1 lc3 lysosomal malin myoclonus overaccumulation proteasomal s6 slight speculate starvation ubiquitinated
Tagcloud (Difference) ?		allows autophagic biosynthesis dephosphorylates downregulated downregulates e3 enhancement excess fatal glucan glycogenic interacts ligase neuron phosphatase physically r6 recruited subunits targeting ubiquitination	arms autophago biogenesis branched chop defects disposal encode epm2b hyperphosphorylated insoluble knock laforinmalin lamp1 lc3 lysosomal overaccumulation proteasomal s6 slight speculate starvation ubiquitinated
Tagcloud (Intersection) ?		epilepsy glycogen lafora laforin malin myoclonus