SLC39A7 and CLCA4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SLC39A7	CLCA4
Name		solute carrier family 39 member 7	chloride channel accessory 4
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane	Extracellular Region Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Metal Ion Transmembrane Transporter Activity	Metalloendopeptidase Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Metal Ion Transport B Cell Differentiation Transmembrane Transport Zinc Ion Transmembrane Transport Skin Epidermis Development Regulation Of Ferroptosis	Proteolysis Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Zinc influx into cells by the SLC39 gene family	Stimuli-sensing channels
GWAS		No GWAS studies recorded	Fasting glucose ( 34074324 )
Novel Interactors		1 novel interactors: STARD3	None recorded
Interacting Genes		29 interacting genes: AQP6 BIK CLCA4 CRCT1 ERCC6 GJA8 KCNF1 KRTAP1-3 KRTAP5-7 KRTAP9-2 LCE1A LCE1C LCE1F LCE2C LCE2D LCE4A LCE5A LELP1 RGS17 RSPO2 SHISAL1 SLC34A2 SMCP SPRY3 TMEM14B TNFRSF10D UNC93A WFDC12 YY1	23 interacting genes: AQP2 BDKRB2 ELOVL4 ERGIC3 FAM209A FCER1G FKBP7 GPR42 LMNA MCFD2 MGST3 PANX1 RETREG3 SCN3B SLC22A23 SLC35E2A SLC39A2 SLC39A7 SPN THAP4 TMEM154 TMEM179B TMEM51
Entrez ID		7922	22802
HPRD ID		09028	16719
Ensembl ID		ENSG00000112473	ENSG00000016602
Uniprot IDs		A0A024RCX7 B4DZZ8 Q92504	Q14CN2
PDB IDs		8GZE	Not available
GO Terms Enriched among Interactors		Keratinization Epidermis Development Tissue Development	Membrane Transmembrane Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Endoplasmic Reticulum Membrane Endoplasmic Reticulum Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport