SLC39A7 and SLC34A2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SLC39A7	SLC34A2
Name		solute carrier family 39 member 7	solute carrier family 34 member 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Vesicle
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Metal Ion Transmembrane Transporter Activity	Sodium:phosphate Symporter Activity Protein Binding Symporter Activity Sodium Ion Binding Phosphate Ion Binding
	Biological Process	Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Metal Ion Transport B Cell Differentiation Transmembrane Transport Zinc Ion Transmembrane Transport Skin Epidermis Development Regulation Of Ferroptosis	In Utero Embryonic Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Intracellular Phosphate Ion Homeostasis Sodium Ion Transmembrane Transport Response To Estrogen Sodium-dependent Phosphate Transport Transmembrane Transport
Pathways		Zinc influx into cells by the SLC39 gene family	Type II Na+/Pi cotransporters Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) Surfactant metabolism Defective SLC34A2 causes PALM
Diseases		None	Non-small cell lung cancer
GWAS		No GWAS studies recorded	Metabolite levels ( 23823483 )
Interacting Genes		29 interacting genes: AQP6 BIK CLCA4 CRCT1 ERCC6 GJA8 KCNF1 KRTAP1-3 KRTAP5-7 KRTAP9-2 LCE1A LCE1C LCE1F LCE2C LCE2D LCE4A LCE5A LELP1 RGS17 RSPO2 SHISAL1 SLC34A2 SMCP SPRY3 TMEM14B TNFRSF10D UNC93A WFDC12 YY1	19 interacting genes: AIG1 ERG28 FXYD6-FXYD2 GUCA2A JAGN1 LHFPL5 PLN PNLIPRP1 RTP2 SLC30A3 SLC35A1 SLC39A7 STRIT1 TEX264 TMEM128 TMEM239 TMEM42 TRARG1 TSPO2
Entrez ID		7922	10568
HPRD ID		09028	07251
Ensembl ID		ENSG00000112473	ENSG00000157765
Uniprot IDs		A0A024RCX7 B4DZZ8 Q92504	O95436
PDB IDs		8GZE	Not available
GO Terms Enriched among Interactors		Keratinization Epidermis Development Tissue Development	Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Membrane Response To Zinc Ion Endoplasmic Reticulum Membrane Regulation Of Cardiac Muscle Cell Contraction Circadian Sleep/wake Cycle, Sleep Regulation Of ATP-dependent Activity Phospholamban Complex Sarcoplasmic Reticulum Membrane Regulation Of Calcium Ion Import Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Zinc Ion Import Into Synaptic Vesicle CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction