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FBXL15 and SMURF1
Number of citations of the paper that reports this interaction (PMID
21572392
)
6
Data Source:
BioGRID
(enzymatic study)
FBXL15
SMURF1
Gene Name
F-box and leucine-rich repeat protein 15
SMAD specific E3 ubiquitin protein ligase 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
SCF Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Axon
Neuronal Cell Body
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Activin Binding
Ubiquitin Protein Ligase Activity
I-SMAD Binding
R-SMAD Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Dorsal/ventral Pattern Formation
Protein Ubiquitination
Bone Mineralization
Positive Regulation Of BMP Signaling Pathway
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Polyubiquitination
Protein Export From Nucleus
Transforming Growth Factor Beta Receptor Signaling Pathway
Ectoderm Development
Protein Ubiquitination
Cell Differentiation
Negative Regulation Of Ossification
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Receptor Catabolic Process
Protein Localization To Cell Surface
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Loss of Function of TGFBR2 in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGF-beta receptor signaling activates SMADs
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Signaling by BMP
Hedgehog 'on' state
Class I MHC mediated antigen processing & presentation
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
Signaling by Hedgehog
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Inflammatory bowel disease (
23128233
)
Ulcerative colitis (
20228798
)
Protein-Protein Interactions
2 interactors:
HNRNPD
SMURF1
98 interactors:
ANAPC5
AP2B1
APBB2
APP
ARHGAP15
ARHGAP31
ARHGEF9
ARL14
ARL4D
ASH2L
AVEN
AXIN1
CCM2
CDC40
CDK14
CDKL1
CSNK2A2
CUL5
CXXC1
DNAJC7
DUSP13
DVL2
ECSIT
ELP3
ESR1
ETV6
FBXL15
FBXO30
FCHO1
GNG11
GRIPAP1
HDGFRP3
ING2
INPP5B
IRAK2
JUNB
LATS1
LHX9
LIMS1
LONRF3
MAP3K2
MAP3K3
NAA16
NDFIP2
NEDD8
OXSR1
PAK1
PAK1IP1
PDLIM7
PLEKHO1
POLR2A
PSME3
PWP1
RASD2
RHOA
RHPN2
RIPK2
RIT1
RNF11
RNF141
RPS27A
RRP9
RTKN
RUNX3
SASH3
SENP8
SF3A1
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SPG20
SQSTM1
SRSF4
SRSF5
STK35
STRAP
STUB1
TLN1
TNK2
TNNT1
TRAF4
TTC17
UBA52
UBB
UBC
UBE2D3
UBE2L3
UBTF
UBXN1
USP45
USP9X
WDR61
WEE1
WFS1
XPO1
Entrez ID
79176
57154
HPRD ID
18876
06902
Ensembl ID
ENSG00000107872
ENSG00000198742
Uniprot IDs
Q9H469
Q9HCE7
PDB IDs
2LAZ
2LB0
2LB1
2LTX
3PYC
Enriched GO Terms of Interacting Partners
?
Circadian Regulation Of Translation
Ubiquitin-dependent SMAD Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein Localization To Cell Surface
Receptor Catabolic Process
Ectoderm Development
Protein Export From Nucleus
Negative Regulation Of BMP Signaling Pathway
Regulation Of MRNA Stability
Regulation Of RNA Stability
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Translation
BMP Signaling Pathway
Negative Regulation Of Ossification
Receptor Metabolic Process
Regulation Of BMP Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Signal Transduction
Cellular Protein Modification Process
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Modification Process
Positive Regulation Of Cellular Protein Metabolic Process
Signal Transduction
Regulation Of Protein Ubiquitination
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Cellular Response To Organic Substance
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Cellular Protein Metabolic Process
Regulation Of Signal Transduction
Signaling
Positive Regulation Of Metabolic Process
Cell Communication
Cellular Response To Stimulus
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Transferase Activity
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Signaling
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Phosphorylation
Transcription From RNA Polymerase II Promoter
Protein Catabolic Process
Regulation Of Cellular Process
Transcription Initiation From RNA Polymerase II Promoter
Proteolysis Involved In Cellular Protein Catabolic Process
DNA-templated Transcription, Initiation
Cellular Protein Catabolic Process
Response To Organic Substance
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Metabolic Process
Positive Regulation Of Ligase Activity
Response To Stimulus
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Gene Expression
Tagcloud
?
5p
acvr2a
alters
applying
bmp
bmp1a
cleaves
cluster
copyright
dies1
furin
impairs
interferes
mapk3
micrornas
mineralization
mir
osteoblast
osteoblasts
protected
reprogramming
reserved
rights
ski
smad
smad5
systematically
tgfbr3
zfp423
Tagcloud (Difference)
?
5p
acvr2a
alters
applying
bmp
bmp1a
cleaves
cluster
copyright
dies1
furin
impairs
interferes
mapk3
micrornas
mineralization
mir
osteoblast
osteoblasts
protected
reprogramming
reserved
rights
ski
smad
smad5
systematically
tgfbr3
zfp423
Tagcloud (Intersection)
?