FBXL15 and DELEC1

Number of citations of the paper that reports this interaction (PubMedID 23555304)
45

Data Source:
BioGRID (two hybrid)

		FBXL15	DELEC1
Description		F-box and leucine rich repeat protein 15	deleted in esophageal cancer 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Dorsal/ventral Pattern Formation Protein Ubiquitination Bone Mineralization Positive Regulation Of BMP Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Cell Population Proliferation
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CSNK2B DELEC1 HNRNPD RORC SMURF1 UBC	29 interacting genes: BHLHE41 BMAL1 CIPC CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B EZH2 FBXL15 GSK3B NFIL3 NONO NPAS2 NR1D2 PER1 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E RORB RORC
Entrez ID		79176	50514
HPRD ID		18876	16068
Ensembl ID		ENSG00000107872	ENSG00000173077
Uniprot IDs		Q9H469
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Activin Receptor Signaling Pathway Hepatocyte Dedifferentiation Cellular Response To Putrescine Engulfment Of Target By Autophagosome Positive Regulation Of Activin Receptor Signaling Pathway Protein Kinase CK2 Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Viral Life Cycle Symbiont-mediated Disruption Of Host Cell PML Body Release From Viral Latency Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Regulation Of Circadian Rhythm Circadian Regulation Of Translation Circadian Rhythm Ligand-modulated Transcription Factor Activity T-helper 17 Cell Differentiation Activin Receptor Binding	Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein Phosphatase Type 2A Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Circadian Rhythm Protein Kinase CK2 Complex Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process CLOCK-BMAL Transcription Complex E-box Binding Glycogen Metabolic Process Response To Light Stimulus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Polysaccharide Metabolic Process PTW/PP1 Phosphatase Complex Energy Reserve Metabolic Process Regulation Of Metabolic Process Regulation Of Type B Pancreatic Cell Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Protein Serine/threonine Phosphatase Activity Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Phosphatase Regulator Activity
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